About the Authors

Esther Nkuipou-Kenfack

Affiliations Mosaiques Diagnostics GmbH, Hannover, Germany, Department of Toxicology, Hannover Medical School, Hannover, Germany

Flore Duranton

Affiliation RD Néphrologie, Montpellier, France

Nathalie Gayrard

Affiliation RD Néphrologie, Montpellier, France

Àngel Argilés

Affiliations RD Néphrologie, Montpellier, France, Néphrologie Dialyse St Guilhem, Séte, France, Service de Néphrologie, Dialyse Péritonéale et Transplantation, Montpellier, France

Ulrika Lundin

Affiliation Biocrates life sciences AG, Innsbruck, Austria

Klaus M. Weinberger

Affiliations Biocrates life sciences AG, Innsbruck, Austria, sAnalytiCo Ltd, Belfast, United Kingdom, Department of Biomedical Informatics and Mechatronics, Private University for Health Sciences, Medical Informatics and Technology, Hall in Tirol, Austria

Mohammed Dakna

Affiliation Mosaiques Diagnostics GmbH, Hannover, Germany

Christian Delles

Affiliation BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

William Mullen

Affiliation BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

Holger Husi

Affiliation BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

Julie Klein

Affiliation Mosaiques Diagnostics GmbH, Hannover, Germany

Thomas Koeck

Affiliation Mosaiques Diagnostics GmbH, Hannover, Germany

Petra Zürbig

Affiliation Mosaiques Diagnostics GmbH, Hannover, Germany

Harald Mischak

mischak@mosaiques-diagnostics.com

Affiliations Mosaiques Diagnostics GmbH, Hannover, Germany, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

Competing Interests

H. Mischak is the founder and co-owner of Mosaiques Diagnostics, who developed the CE-MS technology for clinical application. E. Nkuipou-Kenfack, M. Dakna, J. Klein, T. Koeck, and P. Zürbig are employees of Mosaiques Diagnostics. U. Lundin was an employee of Biocrates Life Sciences AG. K. Weinberger is a shareholder and consultant of Biocrates Life Sciences AG, who developed the metabolomics platform and kit products for research and diagnostic applications. These issues do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ENK AA HM KW. Performed the experiments: WM NG UL KW. Analyzed the data: MD ENK JK HH PZ TK HM FD AA UL KW. Contributed reagents/materials/analysis tools: HM AA KW. Wrote the paper: ENK HM JK TK CD PZ AA FD MD KW.