About the Authors

Douglas Macdonald

Contributed equally to this work with: Douglas Macdonald, Michela A. Tessari

Douglas.Macdonald@chdifoundation.org

Affiliation CHDI Management/CHDI Foundation, Los Angeles, California, United States of America

Michela A. Tessari

Contributed equally to this work with: Douglas Macdonald, Michela A. Tessari

Affiliation Galapagos B.V., Leiden, The Netherlands

Ivette Boogaard

Affiliation BioFocus, a Charles River company, Leiden, The Netherlands

Melanie Smith

Affiliation BioFocus, a Charles River company, Saffron Walden, United Kingdom

Kristiina Pulli

Affiliation Galapagos B.V., Leiden, The Netherlands

Agnieszka Szynol

Affiliation BioFocus, a Charles River company, Leiden, The Netherlands

Faywell Albertus

Affiliation BioFocus, a Charles River company, Leiden, The Netherlands

Marieke B. A. C. Lamers

Affiliation BioFocus, a Charles River company, Saffron Walden, United Kingdom

Sipke Dijkstra

Affiliation BioFocus, a Charles River company, Leiden, The Netherlands

Daniel Kordt

Affiliation Evotec AG, Hamburg, Germany

Wolfgang Reindl

Affiliation Evotec AG, Hamburg, Germany

Frank Herrmann

Affiliation Evotec AG, Hamburg, Germany

George McAllister

Affiliation BioFocus, a Charles River company, Saffron Walden, United Kingdom

David F. Fischer

These authors also contributed equally to this work.

Affiliation BioFocus, a Charles River company, Leiden, The Netherlands

Ignacio Munoz-Sanjuan

These authors also contributed equally to this work.

Affiliation CHDI Management/CHDI Foundation, Los Angeles, California, United States of America

Competing Interests

DM and IMS are employed by CHDI Management, Inc., as advisors to CHDI Foundation, Inc. MAT, IV, AS, FA, and SD are employed by Galapagos B.V. MS, KP, MBACL, GA, and DFF are employed by BioFocus, a Galapagos company. DK, WR, and FH are employed by Evotec. There are no patents, products in development, or marketed products to declare. This declaration does not alter the authors' adherence to all PLOS ONE policies regarding sharing data and materials.

Author Contributions

Conceived and designed the experiments: DM MAT IB MS KP AS FA MBACL SD DK WR FH GMcA DFF IMS. Performed the experiments: IB MS KP AS FA SD DK WR. Analyzed the data: DM MAT IB MS KP AS FA MBACL SD DK WR FH GMcA DFF IMS. Contributed reagents/materials/analysis tools: DM MS DFF IMS. Wrote the paper: DM MAT DFF IMS.