Genome-Wide Analysis of Loss of Heterozygosity in Breast Infiltrating Ductal Carcinoma Distant Normal Tissue Highlights Arm Specific Enrichment and Expansion across Tumor Stages

Xiaoyang Ruan; Hongfang Liu; Lisa Boardman; Jean-Pierre A. Kocher

doi:10.1371/journal.pone.0095783

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Peer-reviewed

Research Article

Genome-Wide Analysis of Loss of Heterozygosity in Breast Infiltrating Ductal Carcinoma Distant Normal Tissue Highlights Arm Specific Enrichment and Expansion across Tumor Stages

Xiaoyang Ruan,

Affiliation Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Hongfang Liu,

Affiliation Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯
Lisa Boardman,

Affiliation Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Jean-Pierre A. Kocher

* E-mail: kocher.jeanpierre@mayo.edu

Affiliation Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
⨯

Genome-Wide Analysis of Loss of Heterozygosity in Breast Infiltrating Ductal Carcinoma Distant Normal Tissue Highlights Arm Specific Enrichment and Expansion across Tumor Stages

Xiaoyang Ruan,
Hongfang Liu,
Lisa Boardman,
Jean-Pierre A. Kocher

Published: April 18, 2014
https://doi.org/10.1371/journal.pone.0095783

About the Authors

Xiaoyang Ruan

Affiliation Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Hongfang Liu

Affiliation Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Lisa Boardman

Affiliation Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America

Jean-Pierre A. Kocher

* E-mail: kocher.jeanpierre@mayo.edu

Affiliation Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XR HL. Performed the experiments: XR. Analyzed the data: XR. Contributed reagents/materials/analysis tools: XR. Wrote the paper: XR JPK LB.

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Breast cancer
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Cancer genomics
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Cancers and neoplasms
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Single nucleotide polymorphisms
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Blood
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Genetic causes of cancer
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Histology
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Heterozygosity
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