About the Authors
- Sergej Popov
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Contributed equally to this work with: Sergej Popov, Hiroshi Takemori
Affiliation Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden
- Hiroshi Takemori
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Contributed equally to this work with: Sergej Popov, Hiroshi Takemori
Affiliation Laboratory of Cell Signaling and Metabolism, National Institute for Biomedical Innovation, Osaka, Japan
- Takeshi Tokudome
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Affiliation Department of Biochemistry, National Cerebral and Cardiovascular Research Institute, Osaka, Japan
- Yuanjie Mao
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Affiliation Department of Biochemistry, National Cerebral and Cardiovascular Research Institute, Osaka, Japan
- Kentaro Otani
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Affiliation Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Research Institute, Osaka, Japan
- Naoki Mochizuki
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Affiliation Cell Biology, National Cerebral and Cardiovascular Research Institute, Osaka, Japan
- Nuno Pires
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Affiliation BIAL - Portela & Ca, S.A., S. Mamede do Coronado, Portugal
- Maria João Pinho
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Affiliation MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal
- Anders Franco-Cereceda
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Affiliation Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
- Lucia Torielli
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Affiliation Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy
- Mara Ferrandi
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Affiliation Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy
- Anders Hamsten
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Affiliation Cardiovascular Genetics and Genomics, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden
- Patricio Soares-da-Silva
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Affiliations BIAL - Portela & Ca, S.A., S. Mamede do Coronado, Portugal, MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal
- Per Eriksson
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Affiliation Cardiovascular Genetics and Genomics, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden
- Alejandro M. Bertorello
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† Deceased.
Affiliation Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden
- Laura Brion
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* E-mail: laura.brion@ki.se
Affiliation Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden
Competing Interests
Nuno Pires and Patricio Soares-da-Silva were employees of BIAL - Portela & Ca S.A. at the time of the study. This does not alter the authors adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: AMB. Performed the experiments: SP HT TT YM KO NM NP MJP LT MF LB. Analyzed the data: SP HT TT YM KO NM NP MJP AFC LT MF AH PSD PE AMB LB. Wrote the paper: AMB LB. Obtain and provide the human heart biopsies from the surgeries: AFC.