About the Authors

Sergej Popov

Contributed equally to this work with: Sergej Popov, Hiroshi Takemori

Affiliation Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden

Hiroshi Takemori

Contributed equally to this work with: Sergej Popov, Hiroshi Takemori

Affiliation Laboratory of Cell Signaling and Metabolism, National Institute for Biomedical Innovation, Osaka, Japan

Takeshi Tokudome

Affiliation Department of Biochemistry, National Cerebral and Cardiovascular Research Institute, Osaka, Japan

Yuanjie Mao

Affiliation Department of Biochemistry, National Cerebral and Cardiovascular Research Institute, Osaka, Japan

Kentaro Otani

Affiliation Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Research Institute, Osaka, Japan

Naoki Mochizuki

Affiliation Cell Biology, National Cerebral and Cardiovascular Research Institute, Osaka, Japan

Nuno Pires

Affiliation BIAL - Portela & Ca, S.A., S. Mamede do Coronado, Portugal

Maria João Pinho

Affiliation MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal

Anders Franco-Cereceda

Affiliation Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Lucia Torielli

Affiliation Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy

Mara Ferrandi

Affiliation Prassis Sigma-Tau Research Institute, Settimo Milanese, Milan, Italy

Anders Hamsten

Affiliation Cardiovascular Genetics and Genomics, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden

Patricio Soares-da-Silva

Affiliations BIAL - Portela & Ca, S.A., S. Mamede do Coronado, Portugal, MedInUP - Center for Drug Discovery and Innovative Medicines, University of Porto, Porto, Portugal

Per Eriksson

Affiliation Cardiovascular Genetics and Genomics, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden

Alejandro M. Bertorello

† Deceased.

Affiliation Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden

Laura Brion

laura.brion@ki.se

Affiliation Membrane Signaling Networks, Department of Medicine, Karolinska Institutet, CMM, Karolinska University Hospital-Solna, Stockholm, Sweden

Competing Interests

Nuno Pires and Patricio Soares-da-Silva were employees of BIAL - Portela & Ca S.A. at the time of the study. This does not alter the authors adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AMB. Performed the experiments: SP HT TT YM KO NM NP MJP LT MF LB. Analyzed the data: SP HT TT YM KO NM NP MJP AFC LT MF AH PSD PE AMB LB. Wrote the paper: AMB LB. Obtain and provide the human heart biopsies from the surgeries: AFC.