About the Authors

Amit Choudhary

Contributed equally to this work with: Amit Choudhary, Kaihui Hu He

Affiliations Society of Fellows, Harvard University, Cambridge, Massachusetts, United States of America, Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Kaihui Hu He

Contributed equally to this work with: Amit Choudhary, Kaihui Hu He

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Philipp Mertins

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Namrata D. Udeshi

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Vlado Dančík

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Dina Fomina-Yadlin

Current address: Amgen, 1201 Amgen Court, Seattle, Washington, United States of America

Affiliations Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America

Stefan Kubicek

Current address: CeMM Research Center for Molecular Medicine, Vienna, Austria

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Paul A. Clemons

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Stuart L. Schreiber

Affiliations Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Steven A. Carr

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Bridget K. Wagner

bwagner@broadinstitute.org

Affiliation Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts, United States of America

Competing Interests

BKW is a member of the Editorial Board of PLOS ONE. This does not alter the authors' adherence to PLOS ONE editorial policies and criteria. One of the authors, DFY, is a postdoctoral fellow at Amgen. This does not alter the authors adherence to PLOS ONE editorial policies and criteria. The work described in this manuscript was performed when DFY was a graduate student at Harvard and the Broad Institute.

Author Contributions

Conceived and designed the experiments: DFY SK SLS BKW. Performed the experiments: AC KH PM NU DFY SK. Analyzed the data: AC PM NU VD PAC SLS SC BKW. Contributed reagents/materials/analysis tools: PM NU VD. Wrote the paper: AC KH BKW.