About the Authors

Kazuhiko Uchiyama

k-uchi@koto.kpu-m.ac.jp

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Tomohisa Takagi

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yasunori Iwamoto

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Norihiko Kondo

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Tetsuya Okayama

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Naohisa Yoshida

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Kazuhiro Kamada

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Kazuhiro Katada

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Osamu Handa

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Takeshi Ishikawa

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Hiroaki Yasuda

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Junichi Sakagami

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Hideyuki Konishi

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Nobuaki Yagi

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yuji Naito

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Yoshito Itoh

Affiliation Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Competing Interests

Yoshito Itoh and Nobuaki Yagi has an affiliation with a donation-funded department from AstraZeneca Co., Ltd., Eisai Co., Ltd., Otsuka Pharmaceutical Co., Ltd., MSD K.K., Dainippon Sumitomo Pharma Co., Ltd., Chugai Pharmaceutical Co., Ltd., FUJIFILM Medical Co., Ltd. and Merck Serono Co., Ltd. Yuji Naito received scholarship funds from Otsuka Pharmaceutical Co., Ltd. and Takeda Pharmaceutical Co., Ltd. Yoshito Itoh received scholarship funds from MSD K.K. and Bristol-Myers K.K. The other authors have no conflicts of interest to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KU YN Y. Itoh. Performed the experiments: Y. Iwamoto NK. Analyzed the data: TT Y. Iwamoto NK N. Yagi. Contributed reagents/materials/analysis tools: N. Yoshida K. Katada K. Kamada OH TI HY JS HK TO. Wrote the paper: KU YN Y. Iwamoto.