About the Authors

Jun Liu

Affiliation Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China

Guo-Liang Zhang

Affiliation Department of Infectious Disease, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, Anhui, China

Gui-Qin Huang

Affiliation Department of Infectious Disease, Infectious Disease Hospital of Cangzhou City, Cangzhou, Hebei, China

Li Li

Affiliation Department of Infectious Disease, The Fifth People's Hospital of Guiyang City, Guiyang, Guizhou, China

Chun-Ping Li

Affiliation Department of Infectious Disease, Infectious Disease Hospital of Tangshan City, Tangshan, Hebei, China

Mei Wang

Affiliation Department of Infectious Disease, The Fifth People's Hospital of Guiyang City, Guiyang, Guizhou, China

Xiao-Yan Liang

Affiliation Department of Infectious Disease, The Fifth People's Hospital of Guiyang City, Guiyang, Guizhou, China

Di Xie

Affiliation Department of Infectious Disease, The Fifth People's Hospital of Guiyang City, Guiyang, Guizhou, China

Chang-Ming Yang

Affiliation Department of Infectious Disease, The Fifth People's Hospital of Guiyang City, Guiyang, Guizhou, China

Yan Li

Affiliation Department of Infectious Disease, The Fifth People's Hospital of Guiyang City, Guiyang, Guizhou, China

Xiu-Rong Sun

Affiliation Department of Infectious Disease, Infectious Disease Hospital of Cangzhou City, Cangzhou, Hebei, China

Hong-Sen Zhang

Affiliation Department of Infectious Disease, Infectious Disease Hospital of Cangzhou City, Cangzhou, Hebei, China

Bai-Song Wan

Affiliation Department of Infectious Disease, Infectious Disease Hospital of Tangshan City, Tangshan, Hebei, China

Wei-Hua Zhang

Affiliation Department of Infectious Disease, Infectious Disease Hospital of Tangshan City, Tangshan, Hebei, China

Hao Yu

Affiliation Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, Jiangsu, China

Ru-Yang Zhang

Affiliation Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, Jiangsu, China

Ya-Nan Yu

Affiliation Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China

Zhong Wang

wangyongyan2010@sina.cn (YYW); zhonw@vip.sina.com (ZW)

Affiliation Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China

Yong-Yan Wang

wangyongyan2010@sina.cn (YYW); zhonw@vip.sina.com (ZW)

Affiliation Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China

Competing Interests

Kanion Pharmaceutical Co. Ltd provided the drugs used in this trial, but no other support from this company or other organisations for the submitted work; The authors have no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; no other relationships or activities that could appear to have influenced the submitted work. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YYW. Performed the experiments: GLZ GQH LL CPL MW XYL DX CMY YL XRS HSZ BSW WHZ. Analyzed the data: HY RYZ. Wrote the paper: JL YNY ZW.