About the Authors

Shang Guo

Affiliations Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China

Hector Lopez-Marquez

Affiliation Translational Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Kenneth C. Fan

Affiliation Translational Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Edwin Choy

Affiliation Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Gregory Cote

Affiliation Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

David Harmon

Affiliation Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

G. Petur Nielsen

Affiliation Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Cao Yang

Affiliation Department of Orthopaedics, Union Hospital, Huazhong University of Science and Technology, Wuhan, China

Changqing Zhang

Affiliation Shanghai Sixth People’s Hospital affiliated to Shanghai Jiao Tong University, Shanghai, China

Henry Mankin

Affiliation Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Francis J. Hornicek

Affiliation Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Darrell R. Borger

Affiliation Translational Research Laboratory, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Zhenfeng Duan

zduan@mgh.harvard.edu

Affiliation Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Competing Interests

The authors have read the journal’s policy and have the following conflicts: DRB is a paid consultant for Bio-Reference Laboratories, Inc (licensee of SNaPshot). All other authors declare no conflicts of interest. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FJH DRB ZD. Performed the experiments: SG HLM KCF. Analyzed the data: SG HLM KCF EC GC DH GPN CY CZ HM FJH DRB ZD. Contributed reagents/materials/analysis tools: GPN CY HM FJH DRB ZD. Wrote the paper: SG HLM KCF EC GC DH GPN CY CZ HM FJH DRB ZD.