About the Authors

Matteo Pedrelli

Contributed equally to this work with: Matteo Pedrelli, Padideh Davoodpour

Affiliations Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Molecular Nutrition Unit, Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden

Padideh Davoodpour

Contributed equally to this work with: Matteo Pedrelli, Padideh Davoodpour

Current address: Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Affiliation Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

Chiara Degirolamo

Current address: Department of Translational Pharmacology, Consorzio Mario Negri Sud, S.M. Imbaro (CH), Italy

Affiliation Division of Lipid Science, Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States of America

Monica Gomaraschi

Affiliation Department of Pharmacological Sciences, University of Milan, Milan, Italy

Mark Graham

Affiliation Cardiovascular Group, Department of Antisense Drug Discovery, Isis Pharmaceuticals, Inc., Carlsbad, California, United States of America

Alice Ossoli

Affiliation Department of Pharmacological Sciences, University of Milan, Milan, Italy

Lilian Larsson

Affiliation Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden

Laura Calabresi

Affiliation Department of Pharmacological Sciences, University of Milan, Milan, Italy

Jan-Åke Gustafsson

Affiliations Molecular Nutrition Unit, Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, Texas, United States of America

Knut R. Steffensen

Affiliation Molecular Nutrition Unit, Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden

Mats Eriksson

Affiliations Molecular Nutrition Unit, Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden, Department of Medicine, Karolinska Institute, Stockholm, Sweden

Paolo Parini

paolo.parini@ki.se

Affiliations Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden, Molecular Nutrition Unit, Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden

Competing Interests

Mark Graham is an employee and stock holder of Isis Pharmaceuticals Inc. (Carlsbad, CA, USA). Laura Calabresi is a member of the PLOS ONE Editorial Board. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. All the other authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MP PD ME PP. Performed the experiments: MP PD LL. Analyzed the data: MP PD M. Gomaraschi CD AO LL KRS. Contributed reagents/materials/analysis tools: M. Graham LC JAG KRS ME PP. Wrote the paper: MP PD ME PP.