About the Authors

Jun Wang

Affiliations Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America, Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York New York, United States of America

David Land

Affiliation Medisyn Technologies, Inc. Minnetonka, Minnesota, United States of America

Kenjiro Ono

Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University, Kanazawa, Japan

Jorge Galvez

Affiliation Molecular Topology & Drug Design Unit, University of Valencia, Valencia, Spain

Wei Zhao

Affiliation Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

Prashant Vempati

Affiliation Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

John W. Steele

Affiliation Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

Alice Cheng

Affiliation Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

Masahito Yamada

Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University, Kanazawa, Japan

Samara Levine

Affiliation Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

Paolo Mazzola

Affiliation Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America

Giulio M. Pasinetti

giulio.pasinetti@mssm.edu

Affiliations Department of Neurology, Mount Sinai School of Medicine, New York, New York, United States of America, Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, New York New York, United States of America

Competing Interests

We have read the journal's policy and have the following conflicts: David Land is affiliated with Medisyn Technologies, Inc. The authors also hold a patent: “Compositions for treatment of Alzheimer's disease using abeta-reducing and/or abeta-anti-aggregation compounds”. Mount Sinai School of Medicine of New York University, USA, Inc Medisyn Technologies, editors. Patent Application Country: Application: WO; WO; Priority Application Country: US patent WO2010114636. 2010 1007; Patent Application Date: 20100405.; Priority Application Date: 20090403). There are no other patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JW DL MY GMP. Performed the experiments: JW KO JG WZ PV JS AC PM. Analyzed the data: JW JG DL SL GMP. Wrote the paper: JW SL GMP.