Pathogenic Strains of Acanthamoeba Are Recognized by TLR4 and Initiated Inflammatory Responses in the Cornea

Hassan Alizadeh; Trivendra Tripathi; Mahshid Abdi; Ashley Dawn Smith

doi:10.1371/journal.pone.0092375

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Open Access

Peer-reviewed

Research Article

Pathogenic Strains of Acanthamoeba Are Recognized by TLR4 and Initiated Inflammatory Responses in the Cornea

Hassan Alizadeh ,

* E-mail: hassan.alizadeh@unthsc.edu

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America
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Trivendra Tripathi,

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America
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Mahshid Abdi,

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America
⨯
Ashley Dawn Smith

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America
⨯

Pathogenic Strains of Acanthamoeba Are Recognized by TLR4 and Initiated Inflammatory Responses in the Cornea

Hassan Alizadeh,
Trivendra Tripathi,
Mahshid Abdi,
Ashley Dawn Smith

Published: March 14, 2014
https://doi.org/10.1371/journal.pone.0092375

About the Authors

Hassan Alizadeh

* E-mail: hassan.alizadeh@unthsc.edu

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America

Trivendra Tripathi

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America

Mahshid Abdi

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America

Ashley Dawn Smith

Affiliation Department of Cell Biology and Immunology, University of North Texas Health Science Center, and North Texas Eye Research Institute, Fort Worth, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HA. Performed the experiments: TT MA ADS. Analyzed the data: HA TT. Contributed reagents/materials/analysis tools: HA. Wrote the paper: HA TT.

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Cornea
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Acanthamoeba
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Toll-like receptors
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Hamsters
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Trophozoites
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Cytokines
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Enzyme-linked immunoassays
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Epithelial cells
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