Inhibition of TGFβ Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes

Jamie L. Ifkovits; Russell C. Addis; Jonathan A. Epstein; John D. Gearhart

doi:10.1371/journal.pone.0089678

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Open Access

Peer-reviewed

Research Article

Inhibition of TGFβ Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes

Jamie L. Ifkovits ,

* E-mail: Ifkovits@mail.med.upenn.edu (JLI); gearhart@upenn.edu (JDG)

Affiliation Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Russell C. Addis,

Affiliation Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Jonathan A. Epstein,

Affiliation Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
John D. Gearhart

* E-mail: Ifkovits@mail.med.upenn.edu (JLI); gearhart@upenn.edu (JDG)

Affiliation Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Inhibition of TGFβ Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes

Jamie L. Ifkovits,
Russell C. Addis,
Jonathan A. Epstein,
John D. Gearhart

Published: February 26, 2014
https://doi.org/10.1371/journal.pone.0089678

About the Authors

Jamie L. Ifkovits

* E-mail: Ifkovits@mail.med.upenn.edu (JLI); gearhart@upenn.edu (JDG)

Affiliation Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Russell C. Addis

Jonathan A. Epstein

John D. Gearhart

* E-mail: Ifkovits@mail.med.upenn.edu (JLI); gearhart@upenn.edu (JDG)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JLI RCA JAE JDG. Performed the experiments: JLI RCA. Analyzed the data: JLI RCA. Contributed reagents/materials/analysis tools: JAE. Wrote the paper: JLI JDG.

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Sedentary behavior
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Fibroblasts
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Troponin
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Small molecules
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Transcription factors
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Cardiomyocytes
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Gene expression
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Signal inhibition
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