About the Authors
- Tina Kiffer-Moreira
-
Affiliation Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
- Campbell R. Sheen
-
Affiliation Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
- Kellen Cristina da Silva Gasque
-
Affiliation Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
- Mayte Bolean
-
Affiliation Departamento de Química, FFCLRP-USP, Ribeirão Preto, São Paulo, Brazil
- Pietro Ciancaglini
-
Affiliation Departamento de Química, FFCLRP-USP, Ribeirão Preto, São Paulo, Brazil
- Andrea van Elsas
-
Affiliation AM-Pharma BV, Bunnik, The Netherlands
- Marc F. Hoylaerts
-
Affiliation Department of Cardiovascular Sciences, Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium.
- José Luis Millán
-
* E-mail: millan@sanfordburnham.org
Affiliation Sanford Children's Health Research Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
Competing Interests
Dr. Andrea van Elsas, co-author of this paper, is VP of Research of AM Pharma, a company that is now manufacturing the ChimAP described in this paper and conducting clinical trials with this novel protein therapeutic. This study was funded in part by AM Pharma. The authors have the following patent/patent applications relating to material pertinent to this article: Australia: 2008244716, China: ZL 2008 80017810.0, Japan: 5320387, US: 8,557,545, Canada: 2,685,405, Europe: 08741670.7, all entitled: “Modified Phosphatases”. The authors have declared their adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
¶ MFH and JLM are joint senior authors on this work.
Conceived and designed the experiments: JLM MFH PC. Performed the experiments: TK-M CRS KCdSG MB. Analyzed the data: TK-M CRS KCdSG MB PC MFH JLM. Contributed reagents/materials/analysis tools: AvE. Wrote the paper: MFH JLM.