About the Authors

Marion E. Joy

Contributed equally to this work with: Marion E. Joy, Laura L. Vollmer

Affiliation Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Laura L. Vollmer

Contributed equally to this work with: Marion E. Joy, Laura L. Vollmer

Affiliation University of Pittsburgh Drug Discovery Institute, Pittsburgh, Pennsylvania, United States of America

Keren Hulkower

Current address: College of American Pathologists, Northfield, Illinois, United States of America

Affiliation Platypus Technologies, LLC, Madison, Wisconsin, United States of America

Andrew M. Stern

Affiliations Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Drug Discovery Institute, Pittsburgh, Pennsylvania, United States of America

Cameron K. Peterson

† Deceased.

Affiliation University of Pittsburgh Drug Discovery Institute, Pittsburgh, Pennsylvania, United States of America

R. C. “Dutch” Boltz

Affiliations Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Drug Discovery Institute, Pittsburgh, Pennsylvania, United States of America

Partha Roy

avogt@pitt.edu (AV); par19@pitt.edu (PR)

Affiliations Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Magee Women's Research Institute, Pittsburgh, Pennsylvania, United States of America

Andreas Vogt

avogt@pitt.edu (AV); par19@pitt.edu (PR)

Affiliations Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, University of Pittsburgh Drug Discovery Institute, Pittsburgh, Pennsylvania, United States of America

Competing Interests

Keren Hulkower is a past employee of Platypus, LLP. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MEJ LLV KH AMS CKP RCB PR AV. Performed the experiments: MEJ LLV CKP RCB AV. Analyzed the data: MEJ LLV RCB PR AV. Contributed reagents/materials/analysis tools: KH RCB PR AV. Wrote the paper: MEJ LLV KH AMS RCB PR AV.