Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model

Spring Valdivia; Anabela Patrone; Mirta Reynaldo; Mario Perello

doi:10.1371/journal.pone.0087478

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Open Access

Peer-reviewed

Research Article

Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model

Spring Valdivia,

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina
⨯
Anabela Patrone,

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina
⨯
Mirta Reynaldo,

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina
⨯
Mario Perello

* E-mail: marioperello@yahoo.com

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina
⨯

Acute High Fat Diet Consumption Activates the Mesolimbic Circuit and Requires Orexin Signaling in a Mouse Model

Spring Valdivia,
Anabela Patrone,
Mirta Reynaldo,
Mario Perello

Published: January 23, 2014
https://doi.org/10.1371/journal.pone.0087478

About the Authors

Spring Valdivia

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina

Anabela Patrone

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina

Mirta Reynaldo

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina

Mario Perello

* E-mail: marioperello@yahoo.com

Affiliation Laboratory of Neurophysiology; Multidisciplinary Institute of Cell Biology (CONICET/CICPBA), La Plata, Argentina

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SV MP. Performed the experiments: SV AP MR. Analyzed the data: SV AP MR MP. Contributed reagents/materials/analysis tools: MP. Wrote the paper: SV MP.

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Neurons
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Food
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Immunostaining
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Dopamine
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Nerve fibers
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Neural pathways
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Quantitative analysis
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Eating
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