Detrimental Effects of Ethanol and Its Metabolite Acetaldehyde, on First Trimester Human Placental Cell Turnover and Function

Sylvia Lui; Rebecca L. Jones; Nathalie J. Robinson; Susan L. Greenwood; John D. Aplin; Clare L. Tower

doi:10.1371/journal.pone.0087328

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Open Access

Peer-reviewed

Research Article

Detrimental Effects of Ethanol and Its Metabolite Acetaldehyde, on First Trimester Human Placental Cell Turnover and Function

Sylvia Lui ,

* E-mail: sylvia.lui@manchester.ac.uk

Affiliation Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom
⨯
Rebecca L. Jones,

Affiliations Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
⨯
Nathalie J. Robinson,

Affiliations Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
⨯
Susan L. Greenwood,

Affiliations Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
⨯
John D. Aplin,

Affiliations Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
⨯
Clare L. Tower

Affiliations Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom
⨯

Detrimental Effects of Ethanol and Its Metabolite Acetaldehyde, on First Trimester Human Placental Cell Turnover and Function

Sylvia Lui,
Rebecca L. Jones,
Nathalie J. Robinson,
Susan L. Greenwood,
John D. Aplin,
Clare L. Tower

Published: February 4, 2014
https://doi.org/10.1371/journal.pone.0087328

About the Authors

Sylvia Lui

* E-mail: sylvia.lui@manchester.ac.uk

Affiliation Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom

Rebecca L. Jones

Affiliations Maternal and Fetal Health Research Centre, Institute of Human Development, University of Manchester, St. Mary’s Hospital, Manchester, United Kingdom, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

Nathalie J. Robinson

Susan L. Greenwood

John D. Aplin

Clare L. Tower

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SL RLJ CLT JDA SLG. Performed the experiments: SL NJR. Analyzed the data: SL NJR. Wrote the paper: SL RLJ CLT JDA SLG NJR.

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Acetaldehyde
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Ethanol
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Pregnancy
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Alcohol consumption
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Placenta
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Apoptosis
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Trophoblasts
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Blood
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