A Population Model Evaluating the Consequences of the Evolution of Double-Resistance and Tradeoffs on the Benefits of Two-Drug Antibiotic Treatments

Ellsworth M. Campbell; Lin Chao

doi:10.1371/journal.pone.0086971

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Open Access

Peer-reviewed

Research Article

A Population Model Evaluating the Consequences of the Evolution of Double-Resistance and Tradeoffs on the Benefits of Two-Drug Antibiotic Treatments

Ellsworth M. Campbell ,

* E-mail: ells@psu.edu

Current address: Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, Pennsylvania, United States of America

Affiliation Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
⨯
Lin Chao

Affiliation Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
⨯

A Population Model Evaluating the Consequences of the Evolution of Double-Resistance and Tradeoffs on the Benefits of Two-Drug Antibiotic Treatments

Ellsworth M. Campbell,
Lin Chao

Published: January 31, 2014
https://doi.org/10.1371/journal.pone.0086971

About the Authors

Ellsworth M. Campbell

* E-mail: ells@psu.edu

Current address: Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, Pennsylvania, United States of America

Affiliation Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

Lin Chao

Affiliation Section of Ecology, Behavior and Evolution, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EC LC. Performed the experiments: EC. Analyzed the data: EC LC. Contributed reagents/materials/analysis tools: LC. Wrote the paper: EC LC. Algebraic solutions in appendix: LC. Publicly available code on GitHub: EC.

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Antibiotic resistance
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Antibiotics
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Drug therapy
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Microbial evolution
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Bacterial evolution
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Evolutionary biology
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Bacterial diseases
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Convergent evolution
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