About the Authors

Nikolaus R. McFarland

Contributed equally to this work with: Nikolaus R. McFarland, Hemi Dimant

nikolaus.mcfarland@neurology.ufl.edu (NRM); mclean.pamela@mayo.edu (PJM)

Affiliation Center for Translational Research in Neurodegenerative Disease, Department of Neurology, University of Florida, Gainesville, Florida, United States of America

Hemi Dimant

Contributed equally to this work with: Nikolaus R. McFarland, Hemi Dimant

Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Laura Kibuuka

Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Darius Ebrahimi-Fakhari

Affiliation Division of Neurology and Inherited Metabolic Diseases, Children’s Hospital, Heidelberg University Hospital, Ruprecht-Karls University Heidelberg, Heidelberg, Germany

Cody A. Desjardins

Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Karin M. Danzer

Affiliation Deparment of Neurology, Universitatsklinikum Ulm, Ulm, Germany

Michael Danzer

Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Zhanyun Fan

Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Michael A. Schwarzschild

Affiliation MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Warren Hirst

Affiliation Pfizer Neuroscience Research Unit, Cambridge, Massachusetts, United States of America

Pamela J. McLean

nikolaus.mcfarland@neurology.ufl.edu (NRM); mclean.pamela@mayo.edu (PJM)

Affiliation Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, United States of America

Competing Interests

Warren Hirst is employed by Pfizer Neuroscience. He helped provide the drugs for this study which are covered by Pfizer patents: WO 2008130879 (PF-04928473), WO 2006091963(PF-04924868) and WO 2008024977 (PF-04944733). There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: NRM HD PJM. Performed the experiments: NRM HD LK DEF KMD MD. Analyzed the data: NRM HD LK DEF PJM. Contributed reagents/materials/analysis tools: ZF CAD MAS WH. Wrote the paper: NRM HD PJM.