About the Authors

Dermot Reilly

Contributed equally to this work with: Dermot Reilly, Ke Hao

Affiliation Department of Molecular Profiling and Research informatics, Merck Research Laboratories, Merck & Co., Inc., Whitehouse Station, New Jersey, United States of America

Ke Hao

Contributed equally to this work with: Dermot Reilly, Ke Hao

Current address: Department of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Affiliation Department of Molecular Profiling and Research informatics, Merck Research Laboratories, Merck & Co., Inc., Whitehouse Station, New Jersey, United States of America

Majken K. Jensen

Affiliation Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

Cynthia J. Girman

cindy.girman@merck.com

Affiliation Department of Epidemiology, Merck Research Laboratories, Merck & Co., Inc., Whitehouse Station, New Jersey, United States of America

Eric B. Rimm

Affiliations Channing Division of Network Medicine, Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

Dermot Reilly, Ke Hao, and Cynthia J. Girman are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., and may own stock/stock options in Merck. Majken K. Jensen reports genotyping efforts paid for by Merck Research Labs. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials. Eric B. Rimm reports receiving a grant from Merck.

Author Contributions

Conceived and designed the experiments: KH CJG EBR. Performed the experiments: DR KH. Analyzed the data: DR KG MKJ CJG EBR. Wrote the manuscript: DR KG MKJ CJG EBR.