About the Authors

Pieter J. Gaillard

PieterGaillard@toBBB.com

Affiliation to-BBB technologies BV, Leiden, The Netherlands

Chantal C. M. Appeldoorn

Affiliation to-BBB technologies BV, Leiden, The Netherlands

Rick Dorland

Affiliation to-BBB technologies BV, Leiden, The Netherlands

Joan van Kregten

Affiliation to-BBB technologies BV, Leiden, The Netherlands

Francesca Manca

Affiliation to-BBB technologies BV, Leiden, The Netherlands

Danielle J. Vugts

Affiliation Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

Bert Windhorst

Affiliation Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

Guus A. M. S. van Dongen

Affiliation Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands

Helga E. de Vries

Affiliation Blood-Brain Barrier Research Group, Molecular Cell Biology and Immunology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

David Maussang

Affiliation to-BBB technologies BV, Leiden, The Netherlands

Olaf van Tellingen

Affiliation The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AvL), Amsterdam, The Netherlands

Competing Interests

PJ Gaillard, CCM Appeldoorn, D Maussang, J v Kregten, F Manca and R Dorland are employees of to-BBB technologies BV. In addition, PJ Gaillard holds founder shares in to-BBB technologies BV. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PG CA BW GD DM OT. Performed the experiments: CA RD JK FM DV DM. Analyzed the data: PG DV BW GD HV DM OT. Wrote the paper: PG OT. Read and approved the manuscript: PG CA RD JK FM DV BW GD HV DM OT.