About the Authors

Jonathan D. Mosley

Affiliation Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Sara L. Van Driest

Affiliation Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, United States of America

Emma K. Larkin

Affiliation Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Peter E. Weeke

Affiliation Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

John S. Witte

Affiliation Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America

Quinn S. Wells

Affiliation Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Jason H. Karnes

Affiliation Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Yan Guo

Affiliation Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America

Lisa Bastarache

Affiliation Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America

Lana M. Olson

Affiliation Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

Catherine A. McCarty

Affiliation Essentia Institute of Rural Health, Duluth, Minnesota, United States of America

Jennifer A. Pacheco

Affiliation Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

Gail P. Jarvik

Affiliation Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, Washington, United States of America

David S. Carrell

Affiliation Group Health Research Institute, Seattle, Washington, United States of America

Eric B. Larson

Affiliation Group Health Research Institute, Seattle, Washington, United States of America

David R. Crosslin

Affiliation Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, Washington, United States of America

Iftikhar J. Kullo

Affiliation Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America

Gerard Tromp

Affiliation The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania, United States of America

Helena Kuivaniemi

Affiliation The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania, United States of America

David J. Carey

Affiliation The Sigfried and Janet Weis Center for Research, Geisinger Health System, Danville, Pennsylvania, United States of America

Marylyn D. Ritchie

Affiliation Department of Biochemistry and Molecular Biology, Penn State University, University Park, Pennsylvania, United States of America

Josh C. Denny

Affiliations Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America, Biomedical Informatics, Vanderbilt University, Nashville, Tennessee, United States of America

Dan M. Roden

dan.roden@vanderbilt.edu

Affiliation Department of Medicine, Vanderbilt University, Nashville, Tennessee, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDM JCD DMR. Performed the experiments: SLV JHK QSW PW JDM. Analyzed the data: SLV JHK QSW PW EKL JSW. Contributed reagents/materials/analysis tools: CAM JAP GPJ DSC EBL DRC JIK GT HK DJC MDR LB YG LMO. Wrote the paper: JDM.