The Exosome Cofactor Rrp47 Is Critical for the Stability and Normal Expression of Its Associated Exoribonuclease Rrp6 in Saccharomyces cerevisiae

Monika Feigenbutz; William Garland; Martin Turner; Phil Mitchell

doi:10.1371/journal.pone.0080752

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Open Access

Peer-reviewed

Research Article

The Exosome Cofactor Rrp47 Is Critical for the Stability and Normal Expression of Its Associated Exoribonuclease Rrp6 in Saccharomyces cerevisiae

Monika Feigenbutz,

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom
⨯
William Garland,

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom
⨯
Martin Turner,

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom
⨯
Phil Mitchell

* E-mail: p.j.mitchell@shef.ac.uk

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom
⨯

The Exosome Cofactor Rrp47 Is Critical for the Stability and Normal Expression of Its Associated Exoribonuclease Rrp6 in Saccharomyces cerevisiae

Monika Feigenbutz,
William Garland,
Martin Turner,
Phil Mitchell

Published: November 5, 2013
https://doi.org/10.1371/journal.pone.0080752

About the Authors

Monika Feigenbutz

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom

William Garland

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom

Martin Turner

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom

Phil Mitchell

* E-mail: p.j.mitchell@shef.ac.uk

Affiliation Molecular Biology and Biotechnology Department, The University of Sheffield, Sheffield, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MF WG PM. Performed the experiments: MF WG MT. Analyzed the data: MF PM. Contributed reagents/materials/analysis tools: MF WG MT. Wrote the manuscript: PM.

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Small nucleolar RNA
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Exosomes
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RNA analysis
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Ribonucleases
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Plasmid construction
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Yeast
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Cell fusion
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RNA processing
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