About the Authors

Kamal Ivory

Contributed equally to this work with: Kamal Ivory, Andrew M. Wilson

kamal.ivory@ifr.ac.uk

Affiliation Gut Health and Food Safety Strategic Programme, Institute of Food Research, Colney, Norwich, United Kingdom

Andrew M. Wilson

Contributed equally to this work with: Kamal Ivory, Andrew M. Wilson

Affiliation Norwich Medical School, University of East Anglia, Norwich, United Kingdom

Prasanna Sankaran

Affiliation Norwich Medical School, University of East Anglia, Norwich, United Kingdom

Marta Westwood

Affiliation Gut Health and Food Safety Strategic Programme, Institute of Food Research, Colney, Norwich, United Kingdom

Justin McCarville

Affiliation Gut Health and Food Safety Strategic Programme, Institute of Food Research, Colney, Norwich, United Kingdom

Claire Brockwell

Affiliation Norwich Medical School, University of East Anglia, Norwich, United Kingdom

Allan Clark

Affiliation Norwich Medical School, University of East Anglia, Norwich, United Kingdom

Jack R. Dainty

Affiliation Gut Health and Food Safety Strategic Programme, Institute of Food Research, Colney, Norwich, United Kingdom

Laurian Zuidmeer-Jongejan

Affiliation Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands

Claudio Nicoletti

Affiliation Gut Health and Food Safety Strategic Programme, Institute of Food Research, Colney, Norwich, United Kingdom

Competing Interests

The study was funded by Yakult Honsha Ltd. and it was conducted as a doubleblinded, placebo-controlled clinical trial. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed clinical and laboratory protocols: AMW KI CN. Performed the experiments: KI MW JMcC L Z-J AMW PS. Analyzed the data: KI MW PS LZ-J AMW JRD AC. Wrote the paper: KI AMW CN. Patient recruitment and visit coordination: CB. Patient contact: CB. Organisation of study drink receipt and distribution: KI.