About the Authors

Barbara Dhooghe

Affiliation Louvain centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain, Brussels, Belgium

Sabrina Noël

Affiliation Louvain centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain, Brussels, Belgium

Caroline Bouzin

Affiliation IREC Imaging Platform/Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain, Brussels, Belgium

Gaëtane Behets-Wydemans

Affiliation IREC Imaging Platform/Pole of Pharmacology and Therapeutics, Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain, Brussels, Belgium

Teresinha Leal

teresinha.leal@uclouvain.be

Affiliation Louvain centre for Toxicology and Applied Pharmacology (LTAP), Institute of Experimental and Clinical Research (IREC), Université catholique de Louvain, Brussels, Belgium

Competing Interests

Vardenafil was kindly provided by Bayer Pharma. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: BD SN TL. Performed the experiments: BD. Analyzed the data: BD SN CB TL. Contributed reagents/materials/analysis tools: CB. Wrote the paper: BD TL. Cell imaging data analyses: BD GBW CB.