About the Authors

Jere E. Meredith Jr.

Contributed equally to this work with: Jere E. Meredith Jr., Sethu Sankaranarayanan

jere.meredith@bms.com

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Sethu Sankaranarayanan

Contributed equally to this work with: Jere E. Meredith Jr., Sethu Sankaranarayanan

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Valerie Guss

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Anthony J. Lanzetti

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Flora Berisha

Affiliation Research and Development, Bristol-Myers Squibb, Lawrenceville, New Jersey, United States of America

Robert J. Neely

Affiliation Research and Development, Bristol-Myers Squibb, Lawrenceville, New Jersey, United States of America

J. Randall Slemmon

Current address: Janssen PRD, Titusville, New Jersey, United States of America

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Erik Portelius

Affiliation Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

Henrik Zetterberg

Affiliation UCL Institute of Neurology, London, United Kingdom

Kaj Blennow

Affiliation Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden

Holly Soares

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Michael Ahlijanian

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Charles F. Albright

Affiliation Research and Development, Bristol-Myers Squibb, Wallingford, Connecticut, United States of America

Competing Interests

The authors JM, SS, VG, AL, FB, RN, JRS, HS, MA and CA are/were employees of Bristol-Myers Squibb. KB has served on Advisory Boards for Innogenetics (Ghent, Belgium) and Roche (Basel, Switzerland). This work is included in US Patent Application: [PLEASE PROVIDE NAME] and number 61/671,397 (SS, JM, VG). There are no further patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JM SS VG AL RS HS MA CA. Performed the experiments: SS VG AL FB RN. Analyzed the data: JM SS VG AL FB RN. Contributed reagents/materials/analysis tools: EP HZ KB. Wrote the manuscript: JM SS VG AL FB RN RS EP HZ KB HS MA CA.