Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm?

Goran Bjelakovic; Dimitrinka Nikolova; Christian Gluud

doi:10.1371/journal.pone.0074558

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Peer-reviewed

Research Article

Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm?

Goran Bjelakovic ,

* E-mail: goranb@junis.ni.ac.rs

Affiliations Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, Department of Internal Medicine, Gastroenterology and Hepatology, Medical Faculty, University of Nis, Niš, Serbia
⨯
Dimitrinka Nikolova,

Affiliation Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
⨯
Christian Gluud

Affiliations Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
⨯

Meta-Regression Analyses, Meta-Analyses, and Trial Sequential Analyses of the Effects of Supplementation with Beta-Carotene, Vitamin A, and Vitamin E Singly or in Different Combinations on All-Cause Mortality: Do We Have Evidence for Lack of Harm?

Goran Bjelakovic,
Dimitrinka Nikolova,
Christian Gluud

Published: September 6, 2013
https://doi.org/10.1371/journal.pone.0074558

About the Authors

Goran Bjelakovic

* E-mail: goranb@junis.ni.ac.rs

Affiliations Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, Department of Internal Medicine, Gastroenterology and Hepatology, Medical Faculty, University of Nis, Niš, Serbia

Dimitrinka Nikolova

Affiliation Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Christian Gluud

Affiliations Cochrane Hepato-Biliary Group, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GB DN CG. Performed the experiments: GB DN CG. Analyzed the data: GB CG. Contributed reagents/materials/analysis tools: GB DN CG. Wrote the manuscript: GB DN CG.

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Vitamin A
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Vitamin E
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Antioxidants
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Medical risk factors
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Metaanalysis
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Death rates
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Diet
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Vitamins
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