About the Authors

Freddie M. Kibengo

Affiliation Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda

Eugene Ruzagira

Affiliation Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda

David Katende

Affiliation Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda

Agnes N. Bwanika

Affiliation Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda

Ubaldo Bahemuka

Affiliation Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda

Jessica E. Haberer

Affiliation Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

David R. Bangsberg

Affiliation Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Burc Barin

Affiliation The EMMES Corporation, Rockville, Maryland, United States of America

James F. Rooney

Affiliation Gilead, Foster City, California, United States of America

David Mark

Affiliation International AIDS Vaccine Initiative, Nairobi, Kenya

Paramesh Chetty

Affiliation International AIDS Vaccine Initiative, Johannesburg, South Africa

Patricia Fast

Affiliation International AIDS Vaccine Initiative, New York, New York, United States of America

Anatoli Kamali

Affiliation Medical Research Council (MRC)/Uganda Virus Research Institute (UVRI) Uganda Research Unit on AIDS, Entebbe, Uganda

Frances H. Priddy

*E-mail: fpriddy@iavi.org

Affiliation International AIDS Vaccine Initiative, New York, New York, United States of America

Competing Interests

Gilead Sciences provided the study drug and placebo tablets at no cost. Co-author James Rooney is employed by Gilead Sciences. Gilead Sciences developed and is marketing the study drug, Truvada, for treatment of HIV infection. Co-author Burc Barin is employed by the EMMES Corporation, and does not have any relevant declarations relating to consultancy, patents, products in development or marketed products. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AK JEH DRB BB PF FHP DM. Performed the experiments: FMK ER DK UB ANB PC. Analyzed the data: BB. Contributed reagents/materials/analysis tools: DM JFR. Wrote the manuscript: FMK ER DK ANB UB AK JEH DRB BB JFR PF FHP. N/A.