About the Authors

Alison P. Klein

aklein1@jhmi.edu

Affiliations Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States of America, Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

Sara Lindström

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America

Julie B. Mendelsohn

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Emily Steplowski

Affiliation Information Management Services, Silver Spring, Maryland, United States of America

Alan A. Arslan

Affiliations Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, United States of America, Department of Environmental Medicine, New York University School of Medicine, New York, New York, United States of America, New York University Cancer Institute, New York, New York, United States of America

H. Bas Bueno-de-Mesquita

Affiliations National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands

Charles S. Fuchs

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Steven Gallinger

Affiliation Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

Myron Gross

Affiliation Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America

Kathy Helzlsouer

Affiliations Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland, United States of America, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States of America

Elizabeth A. Holly

Affiliation Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California, United States of America

Eric J. Jacobs

Affiliation Department of Epidemiology, American Cancer Society, Atlanta, Georgia, United States of America

Andrea LaCroix

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Donghui Li

Affiliation Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

Margaret T. Mandelson

Affiliations Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Group Health Center for Health Studies, Seattle, Washington, United States of America

Sara H. Olson

Affiliation Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Gloria M. Petersen

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Harvey A. Risch

Affiliation Department of Epidemiology and Public Health, Yale University School of Public Health, School of Medicine, New Haven, Connecticut, United States of America

Rachael Z. Stolzenberg-Solomon

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Wei Zheng

Affiliation Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America

Laufey Amundadottir

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Demetrius Albanes

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Naomi E. Allen

Affiliations Cancer Epidemiology Unit, University of Oxford, Nuffield department of Clinical Medicine, Oxford, United Kingdom, UK Biobank, Oxford, United Kingdom

William R. Bamlet

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Marie-Christine Boutron-Ruault

Affiliation Inserm, (Institut National de la Santé et de la Recherche Médicale) and Institut Gustave Roussy, Villejuif, France

Julie E. Buring

Affiliations Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, United States of America

Paige M. Bracci

Affiliation Department of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, California, United States of America

Federico Canzian

Affiliation Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Sandra Clipp

Affiliation George W. Comstock Center for Public Health Research and Prevention, Hagerstown, Maryland, United States of America

Michelle Cotterchio

Affiliation Cancer Care Ontario and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada

Eric J. Duell

Affiliation Unit of Nutrition, Environment and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain

Joanne Elena

Affiliation Division of Cancer Control and Population Science, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America

J. Michael Gaziano

Affiliations Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts, United States of America

Edward L. Giovannucci

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

Michael Goggins

Affiliation Departments of Oncology, Pathology and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Göran Hallmans

Affiliation Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden

Manal Hassan

Affiliation Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

Amy Hutchinson

Affiliation Core Genotyping Facility, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland, United States of America

David J. Hunter

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America

Charles Kooperberg

Affiliation Program in Biostatistics and Biomathematics, Division of Public Health, Fred Hutchinson Cancer Research Center, Seattle, Washington, Massachusetts, United States of America

Robert C. Kurtz

Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

Simin Liu

Affiliation Departments of Epidemiology, Medicine and Obstetrics & Gynecology Director, Center for Metabolic Disease Prevention, University of California Los Angeles, Los Angeles, California, United States of America

Kim Overvad

Affiliation Section of Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark

Domenico Palli

Affiliation Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO Florence, Italy

Alpa V. Patel

Affiliation Department of Epidemiology, American Cancer Society, Atlanta, Georgia, United States of America

Kari G. Rabe

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Xiao-Ou Shu

Affiliation Department of Medicine and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America

Nadia Slimani

Affiliation International Agency for Research on Cancer, Lyon, France

Geoffrey S. Tobias

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Dimitrios Trichopoulos

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece

Stephen K. Van Den Eeden

Affiliation Division of Research, Kaiser Permanente, Northern California Region, Oakland, California, United States of America

Paolo Vineis

Affiliation Imperial College London, London, United Kingdom

Jarmo Virtamo

Affiliation Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland

Jean Wactawski-Wende

Affiliation Department of Social and Preventive Medicine, University at Buffalo, State University of New York Buffalo, Buffalo, New York, United States of America

Brian M. Wolpin

Affiliations Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Herbert Yu

Affiliation Department of Epidemiology and Public Health, Yale University School of Public Health, School of Medicine, New Haven, Connecticut, United States of America

Kai Yu

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Anne Zeleniuch-Jacquotte

Affiliations Department of Environmental Medicine, New York University School of Medicine, New York, New York, United States of America, New York University Cancer Institute, New York, New York, United States of America

Stephen J. Chanock

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Robert N. Hoover

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Patricia Hartge

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland, United States of America

Peter Kraft

Affiliations Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

Competing Interests

The authors have read the journal's policy and have the following conflicts to report: Licensing for gene discovery (Myriad Genetics) for co-discovering PALB2 mutations in pancreatic cancer (MG, AK). Consultant or advisory role for Genentech, Roche, Pfizer, Amgen, Genomic Heath, Metamark Genomics, Imclone, Sanofi (CF). These conflicts does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: APK JBM HBBM CF GMP LA MH GT SJC RH PH PK. Performed the experiments: APK AAA HBBM CF SG M. Gross KH EH EJ AL DL MM SO GMP HAR RZS WZ LA DA WB MB JB PB FC SC MC M. Goggins EG GH DH RK S. Liu KO DP KR XS NS DT SV PV JV BW HY KY AZ PK. Analyzed the data: APK S. Lindström JBM ES CF LA NA ED JE M. Gross EG M. Goggins GH DH AH CK RK S. Liu KO DP AP KR XS NS GT DT SV PV JV JW BW HY KY AZ SJC RH PH PK. Contributed reagents/materials/analysis tools: APK AAA HBBM CF SG M. Gross KH EH EJ AL DL MM SO GMP HAR RZS WZ LA DA WB MB JB PB FC SC MC M. Goggins EG GH DH RK S. Liu KO DP KR XS NS DT SV PV JV BW HY KY AZ PK. Wrote the paper: APK S. Lindström JBM ES AAA HBBM CF SG M. Gross KH EH EJ AL DL MM SO GMP HAR RZS WZ LA DA NA WB MB JB PB FC SC MC ED JE JMG EG M. Goggins GH DH AH CK RK S. Liu KO DP AP KR XS NS GT DT SV PV JV JW BW HY KY AZ SJC RH PH PK.