About the Authors

Jason A. Scott

Affiliations Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Iowa City VA Medical Center, Iowa City, Iowa, United States of America

Paula J. Klutho

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Ramzi El Accaoui

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Emily Nguyen

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Ashlee N. Venema

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Litao Xie

Affiliations Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Iowa City VA Medical Center, Iowa City, Iowa, United States of America

Shuxia Jiang

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Megan Dibbern

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Sabrina Scroggins

Affiliation Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Anand M. Prasad

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Elisabeth D. Luczak

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Melissa K. Davis

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Weiwei Li

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Xiaoqun Guan

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Johannes Backs

Affiliation Department of Cardiology, University of Heidelberg, Heidelberg, Germany

Annette J. Schlueter

Affiliation Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Robert M. Weiss

Affiliation Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Francis J. Miller

Affiliations Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Iowa City VA Medical Center, Iowa City, Iowa, United States of America

Mark E. Anderson

Affiliations Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Isabella M. Grumbach

isabella-grumbach@uiowa.edu

Affiliations Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America, Iowa City VA Medical Center, Iowa City, Iowa, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAS PJK AJS FJM IMG. Performed the experiments: JAS PJK REA EN ANV LX SJ MD SS AMP EDL MKD LX WL RMW. Analyzed the data: JAS PJK REA EN ANV MD AMP EDL IMG. Contributed reagents/materials/analysis tools: WL XG JB AJS RMW MEA IMG. Wrote the paper: JAS IMG.