About the Authors

Andy Z. X. Zhu

Affiliation Department Pharmacology and Toxicology, University of Toronto, Ontario, Canada

Qian Zhou

Affiliation Department Pharmacology and Toxicology, University of Toronto, Ontario, Canada

Lisa Sanderson Cox

Affiliation Department of Preventive Medicine and Public Health, University of Kansas School of Medicine, Kansas City, Kansas, United States of America

Jasjit S. Ahluwalia

Affiliation Department of Medicine and Center for Health Equity, University of Minnesota Medical School, Minneapolis, Minnesota, United States of America

Neal L. Benowitz

Affiliation Division of Clinical Pharmacology and Experimental Therapeutics, Departments of Medicine and Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Rachel F. Tyndale

r.tyndale@utoronto.ca

Affiliations Department Pharmacology and Toxicology, University of Toronto, Ontario, Canada, Campbell Family Mental Health Research Institute, Center for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Ontario, Canada

Competing Interests

Rachel F. Tyndale has served as a consultant to Novartis and McNeil (less than 2 days per year). Neal L. Benowitz has been a paid consultant to Pfizer, GlaxoSmithKline and McNeil, and has served as a paid expert witness in litigation against tobacco companies. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AZ LSC JSA NLB RFT. Performed the experiments: AZ QZ. Analyzed the data: AZZ RFT. Wrote the paper: AZ QZ LSC JSA NLB RFT.