About the Authors
- Tomi Rantamäki
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Affiliation Neuroscience Center, University of Helsinki, Helsinki, Finland
- Susanna Kemppainen
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Affiliation A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland
- Henri Autio
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Affiliation Neuroscience Center, University of Helsinki, Helsinki, Finland
- Saara Stavén
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Affiliation A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland
- Hennariikka Koivisto
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Affiliation A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland
- Masami Kojima
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Affiliation Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, Osaka, Japan
- Hanna Antila
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Affiliation Neuroscience Center, University of Helsinki, Helsinki, Finland
- Pasi O. Miettinen
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Affiliation A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland
- Elisa Kärkkäinen
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Affiliation A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland
- Nina Karpova
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Affiliation Neuroscience Center, University of Helsinki, Helsinki, Finland
- Liisa Vesa
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Affiliation Neuroscience Center, University of Helsinki, Helsinki, Finland
- Lothar Lindemann
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Affiliation Discovery Neuroscience, F. Hoffmann-La Roche Ltd., Basel, Switzerland
- Marius C. Hoener
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Affiliation Discovery Neuroscience, F. Hoffmann-La Roche Ltd., Basel, Switzerland
- Heikki Tanila
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Affiliations Neuroscience Center, University of Helsinki, Helsinki, Finland, A.I.Virtanen Institute, University of Eastern Finland, Kuopio, Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
- Eero Castrén
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* E-mail: eero.castren@helsinki.fi.
Affiliation Neuroscience Center, University of Helsinki, Helsinki, Finland
Competing Interests
Marius C. Hoener and Lothar Lindemann are employees of F. Hoffmann-La Roche Ltd. Tomi Rantamäki, Hanna Antila and Eero Castrén have developed an analytical method that can be used to detect the levels or modifications (e.g. phosphorylation) of cellular proteins (FIN/US Provisional patent pending). This method can be used to screen for regulators of TrkB receptor signaling. This method has not been used in the current study. All other authors declare that they do not have any potential conflicts of interest related to this study.
Author Contributions
Conceived and designed the experiments: TR HT EC. Performed the experiments: TR SK HA SS HK MK HA PM EK NK LV. Analyzed the data: TR MK HT. Contributed reagents/materials/analysis tools: MK LL MH HT EC. Wrote the paper: TR HT EC.