Obesity, Independent of p53 Gene Dosage, Promotes Mammary Tumor Progression and Upregulates the p53 Regulator MicroRNA-504

Nikki A. Ford; Sarah M. Dunlap; Karrie E. Wheatley; Stephen D. Hursting

doi:10.1371/journal.pone.0068089

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Peer-reviewed

Research Article

Obesity, Independent of p53 Gene Dosage, Promotes Mammary Tumor Progression and Upregulates the p53 Regulator MicroRNA-504

Nikki A. Ford,

Affiliation Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America
⨯
Sarah M. Dunlap,

Affiliation Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America
⨯
Karrie E. Wheatley,

Affiliation Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America
⨯
Stephen D. Hursting

* E-mail: shursting@austin.utexas.edu

Affiliations Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America, Department of Molecular Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville, Texas, United States of America
⨯

Obesity, Independent of p53 Gene Dosage, Promotes Mammary Tumor Progression and Upregulates the p53 Regulator MicroRNA-504

Nikki A. Ford,
Sarah M. Dunlap,
Karrie E. Wheatley,
Stephen D. Hursting

Published: June 28, 2013
https://doi.org/10.1371/journal.pone.0068089

About the Authors

Nikki A. Ford

Affiliation Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America

Sarah M. Dunlap

Affiliation Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America

Karrie E. Wheatley

Affiliation Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America

Stephen D. Hursting

* E-mail: shursting@austin.utexas.edu

Affiliations Department of Nutritional Sciences University of Texas at Austin, Austin, Texas, United States of America, Department of Molecular Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NAF KEW SMD SDH. Performed the experiments: KEW SMD NAF. Analyzed the data: NAF. Contributed reagents/materials/analysis tools: SDH. Wrote the paper: SDH KEW SMD NAF.

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Breast cancer
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Breast tumors
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Diet
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Obesity
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Lung and intrathoracic tumors
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Regulator genes
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Tumor suppressor genes
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