About the Authors
- Xueling Sim
-
Contributed equally to this work with: Xueling Sim, Richard A. Jensen, M. Kamran Ikram, Mary Frances Cotch
Affiliation Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America
- Richard A. Jensen
-
Contributed equally to this work with: Xueling Sim, Richard A. Jensen, M. Kamran Ikram, Mary Frances Cotch
Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
- M. Kamran Ikram
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Contributed equally to this work with: Xueling Sim, Richard A. Jensen, M. Kamran Ikram, Mary Frances Cotch
Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
- Mary Frances Cotch
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Contributed equally to this work with: Xueling Sim, Richard A. Jensen, M. Kamran Ikram, Mary Frances Cotch
Affiliation Division of Epidemiology and Clinical Applications, National Eye Institute, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America
- Xiaohui Li
-
Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Stuart MacGregor
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Affiliation Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
- Jing Xie
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Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
- Albert Vernon Smith
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Affiliations Icelandic Heart Association, Kopavogur Capital Region, Iceland, Department of Medicine, University of Iceland, Reykjavik, Iceland
- Eric Boerwinkle
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Affiliation Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
- Paul Mitchell
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Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia
- Ronald Klein
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Affiliation Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
- Barbara E. K. Klein
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Affiliation Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
- Nicole L. Glazer
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Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Medicine, Boston University, Boston, Massachusetts, United States of America
- Thomas Lumley
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Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America, Department of Statistics, University of Auckland, Auckland, New Zealand
- Barbara McKnight
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Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
- Bruce M. Psaty
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Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America, Department of Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America
- Paulus T. V. M. de Jong
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Affiliations Department of Clinical and Molecular Ophthalmogenetics, The Netherlands Institute of Neuroscience, Amsterdam, The Netherlands, Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
- Albert Hofman
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Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
- Fernando Rivadeneira
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Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
- Andre G. Uitterlinden
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Affiliations Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands
- Cornelia M. van Duijn
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Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
- Thor Aspelund
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Affiliations Icelandic Heart Association, Kopavogur Capital Region, Iceland, Department of Medicine, University of Iceland, Reykjavik, Iceland
- Gudny Eiriksdottir
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Affiliation Icelandic Heart Association, Kopavogur Capital Region, Iceland
- Tamara B. Harris
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Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America
- Fridbert Jonasson
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Affiliations Department of Ophthalmology, University of Iceland, Reykjavik, Iceland, Department of Ophthalmology, Landspitalinn University Hospital, Reykjavik, Iceland
- Lenore J. Launer
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Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, United States of America
- The Wellcome Trust Case Control Consortium 2
-
¶Membership of the Wellcome Trust Case Control Consortium 2 is listed in Table S3.
- John Attia
-
Affiliations School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia, Department of Medicine, John Hunter Hospital and Hunter Medical Research Institute, Newcastle, New South Wales, Australia
- Paul N. Baird
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Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
- Stephen Harrap
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Affiliation Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
- Elizabeth G. Holliday
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Affiliation School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia
- Michael Inouye
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Affiliations Immunology Division, Walter and Eliza Hall Institute of Medical Research, Victoria, Australia, Department of Medical Biology, University of Melbourne, Victoria, Australia
- Elena Rochtchina
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Affiliation Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia
- Rodney J. Scott
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Affiliation School of Biomedical Sciences, University of Newcastle, Newcastle, New South Wales, Australia
- Ananth Viswanathan
-
Affiliations National Institutes of Health Research (NIHR) Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, United Kingdom, University College London Institute of Ophthalmology, London, United Kingdom
- Global BPGen Consortium
-
¶Membership of the Global BPgen Consortium is listed in Table S4.
- Guo Li
-
Affiliation Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America
- Nicholas L. Smith
-
Affiliations Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America, Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development, Seattle, Washington, United States of America
- Kerri L. Wiggins
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Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
- Jane Z. Kuo
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Kent D. Taylor
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- Alex W. Hewitt
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Affiliation Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia
- Nicholas G. Martin
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Affiliation Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
- Grant W. Montgomery
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Affiliation Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
- Cong Sun
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Affiliation Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Victoria, Australia
- Terri L. Young
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Affiliation Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, United States of America
- David A. Mackey
-
Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia, Lions Eye Institute, University of Western Australia, Centre for Ophthalmology and Visual Science, Perth, Western Australia, Australia
- Natalie R. van Zuydam
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Affiliation Medical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom
- Alex S. F. Doney
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Affiliation Medical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom
- Colin N. A. Palmer
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Affiliation Medical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom
- Andrew D. Morris
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Affiliation Medical Research Institute, University of Dundee, Dundee, Scotland, United Kingdom
- Jerome I. Rotter
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Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
- E. Shyong Tai
-
¶These authors also contributed equally to this work.
Affiliations Department of Medicine, National University of Singapore, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore
- Vilmundur Gudnason
-
¶These authors also contributed equally to this work.
Affiliations Icelandic Heart Association, Kopavogur Capital Region, Iceland, Department of Medicine, University of Iceland, Reykjavik, Iceland
- Johannes R. Vingerling
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¶These authors also contributed equally to this work.
Affiliations Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
- David S. Siscovick
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¶These authors also contributed equally to this work.
Affiliations Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
- Jie Jin Wang
-
¶These authors also contributed equally to this work.
Affiliations Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia, Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia
- Tien Y. Wong
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* E-mail: tien_yin_wong@nuhs.edu.sg
Affiliations Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore, Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia, Department of Ophthalmology, National University of Singapore, Singapore, Singapore
Competing Interests
The authors declare that Lijf en Leven does not have any competing/conflict of interest and does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: MFC EB PM RK BEKK BMP AH FR AGU CMvD GE TBH FJ LJL WTCCC AV GlobalBPgen DAM ASFD CNAP ADM JIR EST VG JRV DSS JJW TYW. Performed the experiments: MFC EB PM RK BEKK BMP AH FR AGU CMvD GE TBH FJ LJL WTCCC AV GlobalBPgen DAM ASFD CNAP ADM JIR EST VG JRV DSS JJW TYW. Analyzed the data: XS RAJ MKI MFC XL SM JX AVS NLG TL BM TA EGH ER JZK KDT AWH CS NVZ ASFD JIR EST DSS JJW TYW. Contributed reagents/materials/analysis tools: MFC EB PM RK BEKK BMP AH FR AGU CMvD GE TBH FJ LJL WTCCC AV GlobalBPgen DAM ASFD CNAP ADM JIR EST VG JRV DSS JJW TYW. Wrote the paper: XS RAJ MKI MFC XL SM JX AVS EB PM RK BEKK NLG TL BM BMP PTVMdJ CMvD JA PNB SH EGH MI ER RJS GL NLS KLW AWH NGM GWM TLY DAM NVZ ASFD JIR EST VG JRV DSS JJW TYW.