About the Authors

Philip R. Corlett

Contributed equally to this work with: Philip R. Corlett, Victoria Cambridge

philip.corlett@yale.edu

Affiliation Department of Psychiatry, Ribicoff Research Facility, Yale University, New Haven, Connecticut, United States of America

Victoria Cambridge

Contributed equally to this work with: Philip R. Corlett, Victoria Cambridge

Affiliation Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom

Jennifer M. Gardner

Affiliation University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom

Jennifer S. Piggot

Affiliation University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom

Danielle C. Turner

Affiliation Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Jessica C. Everitt

Affiliation Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Fernando Sergio Arana

Affiliation Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom

Hannah L. Morgan

Affiliation Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom

Amy L. Milton

Affiliation Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Jonathan L. Lee

Affiliation University of Birmingham, School of Psychology, Edgbaston, Birmingham, United Kingdom

Michael R. F. Aitken

Affiliation Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Anthony Dickinson

Affiliation Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Barry J. Everitt

Affiliation Department of Psychology, University of Cambridge, Cambridge, United Kingdom

Anthony R. Absalom

Affiliation Department of Anesthesiology, University Medical Center Groningen, Groningen University, Groningen, The Netherlands

Ram Adapa

Affiliation Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom

Naresh Subramanian

Affiliation Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom

Jane R. Taylor

Affiliation Department of Psychiatry, Ribicoff Research Facility, Yale University, New Haven, Connecticut, United States of America

John H. Krystal

Affiliation Department of Psychiatry, Ribicoff Research Facility, Yale University, New Haven, Connecticut, United States of America

Paul C. Fletcher

Affiliations Brain Mapping Unit, Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, United Kingdom, Cambridgeshire and Peterborough NHS Foundation Trust, Elizabeth House, Fulbourn Hospital, Cambridge, United Kingdom

Competing Interests

Philip Corlett reports receiving research support from AstraZeneca Pharmaceuticals, LP and consulting for Pfizer Pharmaceuticals. John Krystal reports consulting for AstraZeneca Pharmaceuticals, LP, Cypress Bioscience, Inc., HoustonPharma, Schering-Plough Research Institute, Shire Pharmaceuticals, and Pfizer Pharmaceuticals; Advisory Boards: Bristol-Myers Squibb, Eli Lilly and Co., Forest Laboratories, GlaxoSmithKline, Lohocla Research Corporation, Merz Pharmaceuticals, Takeda Industries, and Transcept Pharmaceuticals, Inc. Exercisable Warrant Options: Tetragenex Pharmaceuticals Inc.; Research Support: Janssen Research Foundation; Pending Patents: glutamatergic agents for psychiatric disorders (depression, OCD), antidepressant effects of oral ketamine, and oral ketamine for depression. Paul Fletcher has received consultancy fees from GlaxoSmithKline and an honorarium for a lecture from Astra Zeneca. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PRC VC PCF JRT JHK BJE AD MRFA JLL ALM. Performed the experiments: PRC VC JMG JSP DCT JCE FSA HLM ARA RA. Analyzed the data: PRC MRFA PCF NS ARA RA. Contributed reagents/materials/analysis tools: NS. Wrote the paper: PRC PCF JRT JHK JLL BJE ALM.