Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

Reuben Thomas; Russell S. Thomas; Scott S. Auerbach; Christopher J. Portier

doi:10.1371/journal.pone.0063308

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Open Access

Peer-reviewed

Research Article

Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

Reuben Thomas,

Affiliation Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America
⨯
Russell S. Thomas,

Affiliation The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
Scott S. Auerbach,

Affiliation Biomolecular Screening Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America
⨯
Christopher J. Portier

* E-mail: cip7@cdc.gov

Affiliation National Center for Environmental Health and Agency for Toxic Substances and Disease Registry, United States Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯

Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

Reuben Thomas,
Russell S. Thomas,
Scott S. Auerbach,
Christopher J. Portier

Published: May 30, 2013
https://doi.org/10.1371/journal.pone.0063308

About the Authors

Reuben Thomas

Affiliation Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, United States of America

Russell S. Thomas

Affiliation The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, United States of America

Scott S. Auerbach

Affiliation Biomolecular Screening Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America

Christopher J. Portier

* E-mail: cip7@cdc.gov

Affiliation National Center for Environmental Health and Agency for Toxic Substances and Disease Registry, United States Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RST RT CJP. Performed the experiments: RST RT. Analyzed the data: RT RST SSA CJP. Wrote the paper: RT RST SSA CJP.

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Forecasting
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Hepatocellular carcinoma
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Gene expression
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Dose prediction methods
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Cancer risk factors
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Predictive toxicology
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Hepatitis C virus
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Cancer treatment
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