About the Authors

Michael P. Menden

Affiliation European Bioinformatics Institute, Wellcome Trust Genome Campus–Cambridge, Cambridge, United Kingdom

Francesco Iorio

Affiliations European Bioinformatics Institute, Wellcome Trust Genome Campus–Cambridge, Cambridge, United Kingdom, Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus-­Cambridge, Cambridge, United Kingdom

Mathew Garnett

Affiliation Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus-­Cambridge, Cambridge, United Kingdom

Ultan McDermott

Affiliation Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus-­Cambridge, Cambridge, United Kingdom

Cyril H. Benes

Affiliation Center for Molecular Therapeutics, Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts, United States of America

Pedro J. Ballester

pedro.ballester@ebi.ac.uk (PJB); saezrodriguez@ebi.ac.uk (JS-R)

Affiliation European Bioinformatics Institute, Wellcome Trust Genome Campus–Cambridge, Cambridge, United Kingdom

Julio Saez-Rodriguez

pedro.ballester@ebi.ac.uk (PJB); saezrodriguez@ebi.ac.uk (JS-R)

Affiliation European Bioinformatics Institute, Wellcome Trust Genome Campus–Cambridge, Cambridge, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Designed the software and implementation of different approaches: MPM FI PJB. Conceived and designed the experiments: MPM PJB JSR. Performed the experiments: MPM FI PJB. Analyzed the data: MPM FI MG UM CHB PJB JSR. Contributed reagents/materials/analysis tools: MPM FI MG UM CHB PJB. Wrote the paper: MPM CHB PJB JSR.