About the Authors
- Yohannes T. Ghebremariam
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Affiliation Division of Cardiovascular Medicine, Stanford University, Stanford, California, United States of America
- Keisuke Yamada
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Affiliation Division of Cardiovascular Medicine, Stanford University, Stanford, California, United States of America
- Jerry C. Lee
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Affiliation Division of Cardiovascular Medicine, Stanford University, Stanford, California, United States of America
- Christine L. C. Johnson
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Affiliation Department of Pediatrics, Stanford University, Stanford, California, United States of America
- Dorothee Atzler
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Affiliation Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Maike Anderssohn
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Affiliation Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Rani Agrawal
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Affiliation Division of Anesthesia, Stanford University, Stanford, California, United States of America
- John P. Higgins
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Affiliation Division of Pathology, Stanford University, Stanford, California, United States of America
- Andrew J. Patterson
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Affiliation Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Rainer H. Böger
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Affiliation Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- John P Cooke
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* E-mail: john.cooke@stanford.edu
Affiliation Division of Cardiovascular Medicine, Stanford University, Stanford, California, United States of America
Competing Interests
The INT-747 used in this study was provided by Intercept Pharmaceuticals. JPC and YTG are inventors on patents, owned by Stanford University, that protect the use of agents that therapeutically modulate the DDAH/NOS pathway. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived the idea, designed experiments, involved in data collection, data analysis and interpretation: YTG KY JPC. Involved in data collection: JCL CLCJ RA. Involved in data collection and critical revision of manuscript: DA MA RHB. Involved in data collection and data analysis: JPH. Provided financial support and final approval of manuscript: AJP JPC.. Conceived and designed the experiments: YTG KY JPC. Performed the experiments: YTG KY RA CLCJ JCL RA DA MA JPH. Analyzed the data: YTG KY DA MA RA JPH JPC. Contributed reagents/materials/analysis tools: YTG KY DA MA RHB JPH AJP JPC. Wrote the paper: YTG JPC.