About the Authors

Alex E. Roher

alex.roher@bannerhealth.com

Affiliation The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

David H. Cribbs

Affiliations Department of Neurology, University of California Irvine, Irvine, California, United States of America, UCI MIND, University of California Irvine, Irvine, California, United States of America

Ronald C. Kim

Affiliation Department of Pathology, University of California Irivine, Irivine, California, United States of America

Chera L. Maarouf

Affiliation The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Charisse M. Whiteside

Affiliation The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Tyler A. Kokjohn

Affiliations The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona, United States of America, Department of Microbiology, Midwestern University School of Medicine, Glendale, Arizona, United States of America

Ian D. Daugs

Affiliation The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Elizabeth Head

Affiliation Sanders-Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky, United States of America

Carolyn Liebsack

Affiliation Roberts Clinical Center, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Geidy Serrano

Affiliation Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Christine Belden

Affiliation Roberts Clinical Center, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Marwan N. Sabbagh

Affiliation Roberts Clinical Center, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Thomas G. Beach

Affiliation Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona, United States of America

Competing Interests

CB’s salary is supported, in part, by Celgene, Quintiles/Genentech, AVID, Lilly, GE, Wyeth, Bayer, and Pfizer. MNS receives grant support from BMS, Avid, GE, Bayer, Baxter, Wyeth, Janssen, Lilly and Medivation, and is in the consultant/advisory board for Janssen/Pfizer, Amerisciences, Eisai and GSK, and receives royalties from Amerisciences and Wiley. TGB receives funding from AVID-Radiopharmaceuticals, Schering-Bayer Pharmaceuticals and GE Healthcare. None of the above funding was for this specific study. The bapineuzumab used in this study is a Pfizer/Johnson & Johnson/Elan product. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: AER DHC TAK. Performed the experiments: CLM IDD CMW EH GS. Analyzed the data: RCK CLM EH CB CL MNS TGB. Contributed reagents/materials/analysis tools: AER DHC RCK EH. Wrote the paper: AER CLM TAK TGB.