About the Authors

Barney S. Graham

bgraham@nih.gov

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Mary E. Enama

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Martha C. Nason

Affiliation Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Ingelise J. Gordon

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Sheila A. Peel

Affiliation Walter Reed Army Institute of Research, U.S. Military HIV Research Program, Silver Spring, Maryland, United States of America

Julie E. Ledgerwood

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Sarah A. Plummer

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

John R. Mascola

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Robert T. Bailer

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Mario Roederer

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Richard A. Koup

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Gary J. Nabel

Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

the VRC 008 Study Team

Membership of the VRC 008 Study Team is provided in the Acknowledgments.

Competing Interests

GJN is named on patent applications for the candidate vaccines described in the paper. The patents include: 1) HIV vaccines based on Env of multiple clades of HIV, # 7666427; 2) HIV vaccines based on adenoviral vectors encoding Env from multiple clades of HIV, #8323961; 3) Method of using adenoviral vectors to induce an immune response, #WO2005110492; 4) Vaccines against AIDS comprising cmv/r-nucleic acid constructs, #WO2006020071. Lihan Yan and Phyllis Zaia (part of the VRC 008 Study Team) are employed by EMMES Corporation. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: BSG MEE MCN Sarah A Plummer JEL. Performed the experiments: BSG IJG Sarah A Plummer JEL Sheila A Peel JRM RTB MR RAK GJN. Analyzed the data: BSG, MCN, RAK GJN. Contributed reagents/materials/analysis tools: Sheila A Peel JRM RTB MR RK GJN.