Depletion of Cellular Iron by Curcumin Leads to Alteration in Histone Acetylation and Degradation of Sml1p in Saccharomyces cerevisiae

Gajendra Kumar Azad; Vikash Singh; Upendarrao Golla; Raghuvir S. Tomar

doi:10.1371/journal.pone.0059003

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Open Access

Peer-reviewed

Research Article

Depletion of Cellular Iron by Curcumin Leads to Alteration in Histone Acetylation and Degradation of Sml1p in Saccharomyces cerevisiae

Gajendra Kumar Azad,

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India
⨯
Vikash Singh,

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India
⨯
Upendarrao Golla,

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India
⨯
Raghuvir S. Tomar

* E-mail: rst@iiserb.ac.in

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India
⨯

Depletion of Cellular Iron by Curcumin Leads to Alteration in Histone Acetylation and Degradation of Sml1p in Saccharomyces cerevisiae

Gajendra Kumar Azad,
Vikash Singh,
Upendarrao Golla,
Raghuvir S. Tomar

Published: March 8, 2013
https://doi.org/10.1371/journal.pone.0059003

About the Authors

Gajendra Kumar Azad

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India

Vikash Singh

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India

Upendarrao Golla

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India

Raghuvir S. Tomar

* E-mail: rst@iiserb.ac.in

Affiliation Laboratory of Chromatin Biology, Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, India

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RST GKA VS. Performed the experiments: GKA VS. Analyzed the data: GKA VS UG RST. Wrote the paper: GKA VS UG RST.

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Histones
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Yeast
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Chromatin
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Epigenetics
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DNA-binding proteins
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Acetylation
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Saccharomyces cerevisiae
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Epigenetic therapy
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