About the Authors

Akinori Miyashita

Contributed equally to this work with: Akinori Miyashita, Asako Koike, Gyungah Jun

Affiliation Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan

Asako Koike

Contributed equally to this work with: Akinori Miyashita, Asako Koike, Gyungah Jun

Affiliation Central Research Laboratory, Hitachi Ltd, Tokyo, Japan

Gyungah Jun

Contributed equally to this work with: Akinori Miyashita, Asako Koike, Gyungah Jun

Affiliation Departments of Medicine (Biomedical Genetics), Ophthalmology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

Li-San Wang

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Satoshi Takahashi

† Deceased.

Affiliation Department of Neurology, Iwate Medical University, Morioka, Japan

Etsuro Matsubara

Affiliation Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

Takeshi Kawarabayashi

Affiliation Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

Mikio Shoji

Affiliation Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan

Naoki Tomita

Affiliation Department of Geriatric and Complementary Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Hiroyuki Arai

Affiliation Department of Geriatric and Complementary Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan

Takashi Asada

Affiliation Department of Psychiatry, University of Tsukuba, Tsukuba, Japan

Yasuo Harigaya

Affiliation Department of Neurology, Maebashi Red Cross Hospital, Maebashi, Japan

Masaki Ikeda

Affiliation Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan

Masakuni Amari

Affiliation Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan

Haruo Hanyu

Affiliation Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan

Susumu Higuchi

Affiliation Division of Clinical Research, Kurihama Alcoholism Center, Yokosuka, Japan

Takeshi Ikeuchi

Affiliation Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan

Masatoyo Nishizawa

Affiliation Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan

Masaichi Suga

Affiliation Higashi Niigata Hospital, Niigata, Japan

Yasuhiro Kawase

Affiliation Kawase Neurology Clinic, Sanjo, Japan

Hiroyasu Akatsu

Affiliation Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan

Kenji Kosaka

Affiliation Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan

Takayuki Yamamoto

Affiliation Choju Medical Institute, Fukushimura Hospital, Toyohashi, Japan

Masaki Imagawa

Affiliation Imagawa Clinic, Osaka, Japan

Tsuyoshi Hamaguchi

Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

Masahito Yamada

Affiliation Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

Takashi Moriaha

Affiliation Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan

Masatoshi Takeda

Affiliation Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan

Takeo Takao

Affiliation Kurashiki Heisei Hospital, Kurashiki, Japan

Kenji Nakata

Affiliation Kinoko Espoir Hospital, Kasaoka, Japan

Yoshikatsu Fujisawa

† Deceased.

Affiliation Kinoko Espoir Hospital, Kasaoka, Japan

Ken Sasaki

Affiliation Kinoko Espoir Hospital, Kasaoka, Japan

Ken Watanabe

Affiliation Watanabe Hospital, Tottori, Japan

Kenji Nakashima

Affiliation Department of Neurology Tottori University, Yonago, Japan

Katsuya Urakami

Affiliation Department of Biological Regulation, Section of Environment and Health Science, Tottori University, Yonago, Japan

Terumi Ooya

Affiliation Town Office, Onan, Japan

Mitsuo Takahashi

Affiliation Department of Clinical Pharmacology, Fukuoka University, Fukuoka, Japan

Takefumi Yuzuriha

Affiliation Department of Psychiatry, National Hospital Organization, Hizen Psychiatric Center, Saga, Japan

Kayoko Serikawa

Affiliation Ureshino-Onsen Hospital, Saga, Japan

Seishi Yoshimoto

Affiliation Ureshino-Onsen Hospital, Saga, Japan

Ryuji Nakagawa

Affiliation Ureshino-Onsen Hospital, Saga, Japan

Jong-Won Kim

Affiliation Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Chang-Seok Ki

Affiliation Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Hong-Hee Won

Affiliation Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Duk L. Na

Affiliation Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Sang Won Seo

Affiliation Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Inhee Mook-Jung

Affiliation Department of Biochemistry & Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea

The Alzheimer Disease Genetics Consortium

‡ Membership of The Alzheimer Disease Genetics Consortium is provided in the Acknowledgments.

Peter St. George-Hyslop

Affiliation Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada, and the Department of Clinical Neurosciences, Cambridge Institute for Medical Research, Cambridge, United Kingdom

Richard Mayeux

Affiliation Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, United States of America

Jonathan L. Haines

Affiliation Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America

Margaret A. Pericak-Vance

Affiliation The John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, United States of America

Makiko Yoshida

Affiliation Central Research Laboratory, Hitachi Ltd, Tokyo, Japan

Nao Nishida

Affiliation Department of Human Genetics, University of Tokyo, Tokyo, Japan

Katsushi Tokunaga

Affiliation Department of Human Genetics, University of Tokyo, Tokyo, Japan

Ken Yamamoto

Affiliation Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

Shoji Tsuji

Affiliation Department of Neurology, University of Tokyo, Tokyo, Japan

Ichiro Kanazawa

Affiliation National Center for Neurology and Psychiatry, Kodaira, Japan

Yasuo Ihara

Affiliation Department of Neuropathology, Doshisha University, Kyoto, Japan

Gerard D. Schellenberg

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Lindsay A. Farrer

ryosun@bri.niigata-u.ac.jp (RK); farrer@bu.edu (LAF)

These authors also contributed equally to this work.

Affiliations Departments of Medicine (Biomedical Genetics), Ophthalmology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America, Departments of Neurology, Ophthalmology, Genetics & Genomics, and Epidemiology, Boston University Schools of Medicine and Public Health, Boston, Massachusetts, United States of America

Ryozo Kuwano

ryosun@bri.niigata-u.ac.jp (RK); farrer@bu.edu (LAF)

These authors also contributed equally to this work.

Affiliation Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan

Competing Interests

We have the following interests. The Kathleen Price Bryan Brain Bank at Duke University Medical Center is funded by NINDS grant #NS39764, NIMH MH60451 and by Glaxo Smith Kline. Genotyping of the TGEN2 cohort was supported by Kronos Science. Asako Koike and Makiko Yoshida are employed by Central Research Laboratory, Hitachi Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Critical revision of the manuscript for important intellectual content: RM JH MP-V GS LAF RK. Obtained funding: J-WK RM JH MP-V GS LAF RK. Conceived and designed the experiments: JG KT ST J-WK LAF RK. Performed the experiments: AM NN KT KY RK. Analyzed the data: GJ AK L-SW MY AM LAF. Contributed reagents/materials/analysis tools: ST EM TK M. Shoji NT HA TA YH M. Ikeda MA HH SH TI MN TM M. Suga YK HA TY KK M. Imagawa TH MY TT KN YF K. Sasaki KW YW KU TO MT TY K. Serikawa SY RN DLN SWS C-SK H-HW IM-J The Alzheimer's Disease Genetics Consortium PSG-H RM JH MP-V GS LAF IK YI RK. Wrote the paper: GJ AM AK LAF RK.