About the Authors

Jennifer L. Green

Affiliation The Salk Institute for Biological Studies, La Jolla, California, United States of America

Matthieu Bauer

Affiliation Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America

Kyu Won Yum

Affiliation The Salk Institute for Biological Studies, La Jolla, California, United States of America

Yao-Cheng Li

Affiliation The Salk Institute for Biological Studies, La Jolla, California, United States of America

Miranda L. Cox

Affiliation The Salk Institute for Biological Studies, La Jolla, California, United States of America

Karl Willert

Affiliation Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America

Geoffrey M. Wahl

wahl@salk.edu

Affiliation The Salk Institute for Biological Studies, La Jolla, California, United States of America

Competing Interests

The authors have the following conflicts to declare: JLG, YCL and GMW are named as inventors on U.S. Patent Application No. 13/538,755 Methods for Improved Production of Bioactive WNT Proteins. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JLG MB Y-CL MLC KW GMW. Performed the experiments: JLG MB KWY Y-CL MLC. Analyzed the data: JLG MB KWY Y-CL MLC KW GMW. Contributed reagents/materials/analysis tools: JLG MB Y-CL KW GMW. Wrote the paper: JLG MB KWY Y-CL MLC KW GMW.