About the Authors

Rui-Yan Wang

Affiliation MOE Key Lab of Bioinformatics and Systems Biology, Department of Biological Science and Biotechnology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

Zhen-Yu Shi

Affiliation Synthenome.com, Dingley Village, Victoria, Australia

Ying-Ying Guo

Affiliation MOE Key Lab of Bioinformatics and Systems Biology, Department of Biological Science and Biotechnology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

Jin-Chun Chen

Affiliation MOE Key Lab of Bioinformatics and Systems Biology, Department of Biological Science and Biotechnology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China

Guo-Qiang Chen

chengq@mail.tsinghua.edu.cn

Affiliations MOE Key Lab of Bioinformatics and Systems Biology, Department of Biological Science and Biotechnology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, China, Center for Nano and Micro Mechanics, Tsinghua University, Beijing, China

Competing Interests

Co-author Zhen-Yu Shi is employed by “Synthenome.com”: This does not alter the authors′ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

contributed equally to this work: RYW ZYS. Conceived and designed the experiments: ZYS. Performed the experiments: RYW YYG JCC. Analyzed the data: RYW ZYS. Contributed reagents/materials/analysis tools: JCC GQC. Wrote the paper: ZYS RYW GQC.