About the Authors

Mohamed E. Moustafa

Contributed equally to this work with: Mohamed E. Moustafa, Bradley A. Carlson, Miriam R. Anver, Gerd Bobe

Current address: Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Bradley A. Carlson

Contributed equally to this work with: Mohamed E. Moustafa, Bradley A. Carlson, Miriam R. Anver, Gerd Bobe

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Miriam R. Anver

Contributed equally to this work with: Mohamed E. Moustafa, Bradley A. Carlson, Miriam R. Anver, Gerd Bobe

Affiliation Pathology/Histotechnology Laboratory, Science Applications International Corporation-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Gerd Bobe

Contributed equally to this work with: Mohamed E. Moustafa, Bradley A. Carlson, Miriam R. Anver, Gerd Bobe

Affiliation Department of Animal and Rangeland Sciences, College of Agriculture, and Linus Pauling Institute, Oregon State University, Corvallis, Oregon, United States of America

Nianxin Zhong

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Jerrold M. Ward

Affiliation Immunopathology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Christine M. Perella

Affiliation Laboratory Animal Sciences Program, Science Applications International Corporation-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Victoria J. Hoffmann

Affiliation Office of the Director, Diagnostic and Research Services Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Keith Rogers

Current address: Histopathology Laboratory, Institute of Molecular and Cell Biology, Proteos, Singapore

Affiliation Pathology/Histotechnology Laboratory, Science Applications International Corporation-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America

Gerald F. Combs Jr

Affiliation Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota, United States of America

Ulrich Schweizer

Affiliation Charite-Universitatsmedizin Berlin, Institut fur Experimentelle Endokrinologie, Berlin, Germany

Glenn Merlino

Affiliation Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Vadim N. Gladyshev

Affiliation Division of Genetics, Department of Medicine, Brigham & Women’s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Dolph L. Hatfield

hatfield@dc37a.nci.nih.gov

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MEM GM VNG DLH. Performed the experiments: MEM BAC NZ GFC CMP. Analyzed the data: MEM BAC MRA GB JMW VJH KR GFC US VNG DLH. Contributed reagents/materials/analysis tools: GFC DLH GB. Wrote the paper: MEM MRA DLH GB.