About the Authors

Taylor J. Jensen

Contributed equally to this work with: Taylor J. Jensen, Tricia Zwiefelhofer, Roger C. Tim

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Tricia Zwiefelhofer

Contributed equally to this work with: Taylor J. Jensen, Tricia Zwiefelhofer, Roger C. Tim

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Roger C. Tim

Contributed equally to this work with: Taylor J. Jensen, Tricia Zwiefelhofer, Roger C. Tim

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Željko Džakula

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Sung K. Kim

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Amin R. Mazloom

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Zhanyang Zhu

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

John Tynan

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Tim Lu

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Graham McLennan

Affiliation Research and Development, Sequenom Inc., San Diego, California, United States of America

Glenn E. Palomaki

Affiliation Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

Jacob A. Canick

Affiliation Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, United States of America

Paul Oeth

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Cosmin Deciu

Affiliation Research and Development, Sequenom Center for Molecular Medicine, San Diego, California, United States of America

Dirk van den Boom

Affiliation Research and Development, Sequenom Inc., San Diego, California, United States of America

Mathias Ehrich

mehrich@sequenom.com

Affiliation Research and Development, Sequenom Inc., San Diego, California, United States of America

Competing Interests

TJJ, TZ, RCT, ZD, SKK, ARM, ZZ, JT, TL, GM, PO, CD, DvdB, and ME are all employees of Sequenom, Inc. or Sequenom Center for Molecular Medicine, a wholly owned subsidiary of Sequenom, Inc. Each of these authors are also shareholders of Sequenom, Inc. GEP and JAC were members of the Sequenom Clinical Advisory Board for 6 months and resigned when sample collection for this study was funded. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: PO CD DvdB ME GEP JAC. Performed the experiments: TJJ TZ RCT JT. Analyzed the data: TJJ ZD SKK ARM ZZ TL CD ME. Contributed reagents/materials/analysis tools: GEP JAC. Wrote the paper: TJJ TZ GM ME.