About the Authors

Henriikka Salomäki

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Laura H. Vähätalo

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Kirsti Laurila

Affiliations Department of Information and Service Economy, Aalto University School of Economics, Helsinki, Finland, Department of Information and Computer Science, Aalto University School of Science, Helsinki, Finland

Norma T. Jäppinen

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Anna-Maija Penttinen

Current address: Institute of Biotechnology, University of Helsinki, Helsinki, Finland

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Liisa Ailanen

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Juan Ilyasizadeh

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Ullamari Pesonen

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Markku Koulu

markku.koulu@utu.fi

Affiliation Institute of Biomedicine, Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland

Competing Interests

The authors have read the journal's policy and have the following conflicts: Author UP is employed 80% by Orion Corporation/Orion Pharma, Turku, Finland. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Revised the manuscript: LHV KL NTJ A-MP LA JI. Conceived and designed the experiments: HS LHV NTJ UP MK. Performed the experiments: HS LHV A-MP LA NTJ JI. Analyzed the data: HS LHV KL NTJ UP MK. Wrote the paper: HS UP MK.