Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice

Twishasri Dasgupta; Samantha J. Stillwagon; Andrea N. Ladd

doi:10.1371/journal.pone.0056590

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Open Access

Peer-reviewed

Research Article

Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice

Twishasri Dasgupta,

Affiliation Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Samantha J. Stillwagon,

Affiliation Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Andrea N. Ladd

* E-mail: ladda@ccf.org

Affiliation Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯

Gene Expression Analyses Implicate an Alternative Splicing Program in Regulating Contractile Gene Expression and Serum Response Factor Activity in Mice

Twishasri Dasgupta,
Samantha J. Stillwagon,
Andrea N. Ladd

Published: February 20, 2013
https://doi.org/10.1371/journal.pone.0056590

About the Authors

Twishasri Dasgupta

Affiliation Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Samantha J. Stillwagon

Affiliation Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Andrea N. Ladd

* E-mail: ladda@ccf.org

Affiliation Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TD ANL. Performed the experiments: TD SJS ANL. Analyzed the data: TD SJS ANL. Contributed reagents/materials/analysis tools: ANL. Wrote the paper: TD ANL.

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Heart
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Alternative splicing
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Gene expression
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Gene ontologies
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Mouse models
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Genetically modified animals
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Transcription factors
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Microarrays
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