About the Authors

Fabian R. Reimold

Affiliations Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Department of General Internal Medicine and Nephrology, Robert-Bosch Hospital, Stuttgart, Germany

Niko Braun

Affiliations Department of General Internal Medicine and Nephrology, Robert-Bosch Hospital, Stuttgart, Germany, Institute of Digital Medicine, Stuttgart, Germany

Zsuzsanna K. Zsengellér

Affiliation Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

Isaac E. Stillman

Affiliations Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

S. Ananth Karumanchi

Affiliations Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

Hakan R. Toka

Affiliations Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Nephrology and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America

Joerg Latus

Affiliations Department of General Internal Medicine and Nephrology, Robert-Bosch Hospital, Stuttgart, Germany, Institute of Digital Medicine, Stuttgart, Germany

Peter Fritz

Affiliation Division of Pathology, Department of Diagnostic Medicine, Robert-Bosch Hospital, Stuttgart, Germany

Dagmar Biegger

Affiliations Division of Pathology, Department of Diagnostic Medicine, Robert-Bosch Hospital, Stuttgart, Germany, Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany

Stephan Segerer

Affiliation Division of Nephrology, University Hospital Zurich, Zurich, Switzerland

M. Dominik Alscher

Affiliations Department of General Internal Medicine and Nephrology, Robert-Bosch Hospital, Stuttgart, Germany, Institute of Digital Medicine, Stuttgart, Germany

Manoj K. Bhasin

Contributed equally to this work with: Manoj K. Bhasin, Seth L. Alper

Affiliations Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Division of Interdisciplinary Medicine and Biotechnology and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

Seth L. Alper

Contributed equally to this work with: Manoj K. Bhasin, Seth L. Alper

salper@bidmc.harvard.edu

Affiliations Renal Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have the following interests. This study was partly funded by Baxter International, Inc. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: FRR SLA MKB IES ZKZ NB MDA. Performed the experiments: FRR ZKZ NB DB PF. Analyzed the data: FRR SLA MKB IES ZKZ NB DB PF SAK HRT. Contributed reagents/materials/analysis tools: SLA MKB IES ZKZ NB DB PF JL. Wrote the paper: FRR SLA MKB NB SS.