About the Authors

Molly Plovanich

Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Roman L. Bogorad

Affiliation Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Yasemin Sancak

Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Kimberli J. Kamer

Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Laura Strittmatter

Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Andrew A. Li

Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Hany S. Girgis

Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Satya Kuchimanchi

Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Jack De Groot

Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Lauren Speciner

Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Nathan Taneja

Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Jonathan OShea

Affiliation Alnylam Pharmaceuticals, Inc., Cambridge, Massachusetts, United States of America

Victor Koteliansky

Affiliation Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Vamsi K. Mootha

vamsi@hms.harvard.edu

Affiliations Departments of Molecular Biology and Medicine, Massachusetts General Hospital, and Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute, Cambridge, Massachusetts, United States of America

Competing Interests

Please note that in this paper, the authors' academic laboratory (based at Massachusetts General Hospital/Harvard Medical School) collaborated with Alnylam Pharmaceuticals (co-authors include JDG, L. Speciner, NT, JO, VK). As employees, they received compensation/stock from Alnylam. The authors do not believe that the fact that they are employees of a company, receiving salary/equity from this company, represents a competing interest that compromises the objectivity of the work. This does not alter the authors' adherence to all the PLOS ONE policies on data sharing and materials.

Author Contributions

Performed computational analysis: AAL. Designed, validated and produced siRNA reagents: RLB SK JDG L. Speciner NT JO VK. Conceived and designed the experiments: MP VKM RLB YS KJK L. Strittmatter HSG. Performed the experiments: MP RLB YS KJK L. Strittmatter HSG. Analyzed the data: MP RLB YS KJK L. Strittmatter HSG. Wrote the paper: MP VKM.