About the Authors

Sang Cheol Kim

Contributed equally to this work with: Sang Cheol Kim, Yeonjoo Jung, Jinah Park, Sooyoung Cho, Chaehwa Seo, Jaesang Kim

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Yeonjoo Jung

Contributed equally to this work with: Sang Cheol Kim, Yeonjoo Jung, Jinah Park, Sooyoung Cho, Chaehwa Seo, Jaesang Kim

Affiliations Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Jinah Park

Contributed equally to this work with: Sang Cheol Kim, Yeonjoo Jung, Jinah Park, Sooyoung Cho, Chaehwa Seo, Jaesang Kim

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Sooyoung Cho

Contributed equally to this work with: Sang Cheol Kim, Yeonjoo Jung, Jinah Park, Sooyoung Cho, Chaehwa Seo, Jaesang Kim

Affiliations Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Chaehwa Seo

Contributed equally to this work with: Sang Cheol Kim, Yeonjoo Jung, Jinah Park, Sooyoung Cho, Chaehwa Seo, Jaesang Kim

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Jaesang Kim

Contributed equally to this work with: Sang Cheol Kim, Yeonjoo Jung, Jinah Park, Sooyoung Cho, Chaehwa Seo, Jaesang Kim

Affiliations Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Pora Kim

Affiliations Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Jehwan Park

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Jihae Seo

Affiliations Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Jiwoong Kim

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Seongjin Park

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Insu Jang

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Namshin Kim

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Jin Ok Yang

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Byungwook Lee

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Kyoohyoung Rho

Affiliation Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea

Yeonhwa Jung

Affiliations Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Juhee Keum

Affiliations Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Jinseon Lee

Affiliation Samsung Biomedical Research Institute (SBRI) and Cancer Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Jungho Han

Affiliation Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Sangeun Kang

Affiliation Samsung Biomedical Research Institute (SBRI) and Cancer Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Sujin Bae

Affiliation Samsung Biomedical Research Institute (SBRI) and Cancer Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

So-Jung Choi

Affiliation Samsung Biomedical Research Institute (SBRI) and Cancer Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Sujin Kim

Affiliation DNA Link Inc., Seoul, Korea

Jong-Eun Lee

Affiliation DNA Link Inc., Seoul, Korea

Wankyu Kim

Affiliations Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Jhingook Kim

sanghyuk@ewha.ac.kr (SL); jkimsmc@skku.edu (JK)

Affiliations Samsung Biomedical Research Institute (SBRI) and Cancer Research Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

Sanghyuk Lee

sanghyuk@ewha.ac.kr (SL); jkimsmc@skku.edu (JK)

Affiliations Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea, Ewha Research Center for Systems Biology (ERCSB), Ewha Womans University, Seoul, Korea, Division of Life and Pharmaceutical Sciences and the Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea

Competing Interests

The authors acknowledge that two of the authors, Sujin Kim and Jong-Eun Lee belong to a commercial company, DNA Link Inc. The authors duly state here that no competing interests, financial or non-financial, are incurred by this affiliation. Furthermore, this does not alter the authors' adherence to the PLOS ONE policies on sharing data and materials.

Author Contributions

Collected and prepared samples: YJ JL JH SK SB SC. Generated the data: SK JL. Built integrated networks: JP SC JS KR WK. Conceived and designed the experiments: Jaesang Kim Jhingook Kim JL SL. Performed the experiments: Yeonjoo Jung Yeonhwa Jung JK. Analyzed the data: SCK JP SC CS PK JP Jihwoong Kim SP IJ NK JOY BL. Wrote the paper: SL Jaesang Kim Jhingook Kim.